Rabbit Polyclonal UBE1L Antibody

The UBE1L antibody is a research tool designed to detect and study the ubiquitin-activating enzyme E1-like (UBE1L), also known as ubiquitin-like modifier-activating enzyme 1. UBE1L is a key enzyme in the ubiquitin-proteasome system, catalyzing the first step of protein ubiquitination by activating ubiquitin or ubiquitin-like proteins (e.g., ISG15) for conjugation to target substrates. This process regulates critical cellular functions, including protein degradation, DNA repair, and immune responses. UBE1L has gained attention for its role in antiviral defense, where it mediates ISGylation—a post-translational modification linked to interferon signaling. Dysregulation of UBE1L has been implicated in diseases such as cancer, neurodegenerative disorders, and viral infections. For instance, studies suggest UBE1L may suppress tumor growth by promoting degradation of oncoproteins or stabilizing tumor suppressors. In neurodegenerative contexts, it may influence the clearance of misfolded proteins. The UBE1L antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions with other molecules. Researchers also employ it to explore UBE1L's involvement in cellular stress responses and therapeutic pathways. However, antibody specificity and validation remain critical, as cross-reactivity with homologous enzymes (e.g., UBA1) can complicate interpretations. Overall, the UBE1L antibody serves as a vital reagent for dissecting the enzyme's biological roles and its potential as a therapeutic target. (297 words)