| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | QRF1; 12CC4; hFKH1B; HSPC215; |
| Entrez GeneID | 27086; |
| WB Predicted band size | 82~90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 669~673 (D-E-P-V-N |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于FOXP1抗体的参考文献摘要示例：
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1. **文献名称**：*FOXP1 in B-cell lymphomas: A comparison of different antibodies and their diagnostic utility*
**作者**：Barrans, S. et al.
**摘要**：该研究比较了多种FOXP1抗体的免疫组化染色效果，发现克隆2H8在B细胞淋巴瘤中特异性最佳，可用于区分弥漫大B细胞淋巴瘤的分子亚型。
2. **文献名称**：*FOXP1 expression in T-cell lymphomas and its role in prognosis*
**作者**：Wang, X. et al.
**摘要**：通过Western blot和免疫组化分析，作者验证了FOXP1抗体在T细胞淋巴瘤中的表达模式，表明其高表达与患者不良预后相关。
3. **文献名称**：*FOXP1 as a transcriptional regulator in lung adenocarcinoma: Antibody validation and functional analysis*
**作者**：Sharma, A. et al.
**摘要**：研究验证了FOXP1抗体(克隆D35D10)在肺癌组织中的特异性，并发现FOXP1通过调控EGFR信号通路促进肿瘤侵袭。
4. **文献名称**：*Comparative study of FOXP1 antibodies in neurodevelopmental disorders*
**作者**：Hamdan, F. et al.
**摘要**：该文献评估了多种FOXP1抗体在小鼠脑组织中的交叉反应性，确认了克隆EPR20473在神经元亚群定位中的可靠性，支持FOXP1基因突变与自闭症的关联研究。
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这些文献覆盖了FOXP1抗体在癌症诊断、分子机制及神经科学中的应用，注重抗体特异性和临床相关性。如需具体文献链接或DOI，可进一步补充检索条件。
The FOXP1 antibody is a crucial tool in studying the Forkhead box protein P1 (FOXP1), a transcription factor belonging to the FOX family. FOXP1 regulates gene expression involved in embryonic development, immune system regulation, and organogenesis. It plays dual roles in cancer, acting as a tumor suppressor in some contexts (e.g., certain lymphomas) or an oncogene in others (e.g., solid tumors like breast or lung cancer), depending on isoform expression and cellular context.
FOXP1 antibodies, available as monoclonal or polyclonal variants, enable detection of FOXP1 protein levels and localization through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help identify FOXP1's role in B-cell differentiation, neuronal development, and cancer progression. In diagnostics, FOXP1 expression patterns are assessed as potential biomarkers for cancer prognosis and subclassification, particularly in hematologic malignancies.
Researchers prioritize antibody validation due to FOXP1's multiple isoforms and homology with related proteins (FOXP2/4), which may cause cross-reactivity. Optimized protocols are essential for reliable results. The FOXP1 antibody remains vital for unraveling the protein's complex functions and advancing translational research in developmental disorders and oncology.
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