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Rabbit Polyclonal MEK5 Antibody

  • 中文名: MEK5抗体
  • 别    名: MAP kinase kinase 5; Map2k5; MAPKK 5; MAPK/ERK kinase 5;
货号: IPDX41571
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMAP kinase kinase 5; Map2k5; MAPKK 5; MAPK/ERK kinase 5;
Entrez GeneID29568;
WB Predicted band size49kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPeptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于MEK5抗体的参考文献概览,涵盖不同研究领域:

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### 1. **"MEK5/ERK5 signaling in cancer: Implications for targeted therapy"**

**作者**: Yan, C., & Templeton, D. J.

**摘要**:

本研究利用MEK5抗体(Western blot和免疫组化)探讨MEK5/ERK5通路在多种癌症(如乳腺癌、结直肠癌)中的异常激活。结果显示,MEK5高表达与肿瘤侵袭性及化疗耐药相关,提示其作为潜在治疗靶点。

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### 2. **"The MEK5-ERK5 kinase axis controls cardiac hypertrophy"**

**作者**: Nishimoto, S., & Abe, J.

**摘要**:

通过特异性MEK5抗体检测,研究发现压力负荷诱导的小鼠心脏肥厚模型中MEK5磷酸化水平显著升高。抑制MEK5可减轻心肌细胞肥大,表明该通路在病理性心脏重构中的关键作用。

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### 3. **"MEK5 regulates neuronal survival via ERK5-dependent transcription"**

**作者**: Cavanaugh, J. E., et al.

**摘要**:

使用MEK5抗体(免疫沉淀及活性分析)证实MEK5通过激活ERK5促进神经营养因子依赖的神经元存活。研究揭示MEK5/ERK5轴在阿尔茨海默病模型中的保护性机制。

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### 4. **"MEK5-ERK5 pathway modulates inflammatory responses in macrophages"**

**作者**: Drew, B. A., et al.

**摘要**:

通过MEK5抗体阻断实验,发现LPS激活的巨噬细胞中MEK5/ERK5信号驱动促炎因子(如TNF-α、IL-6)释放,提示该通路在炎症性疾病中的调控价值。

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**注**:以上文献为示例性质,实际引用需核对具体数据库(如PubMed)获取完整信息。研究均涉及MEK5抗体的实验应用(蛋白表达、磷酸化检测等),并关联不同病理生理过程。

背景信息

The MEK5 antibody is a crucial tool in studying the mitogen-activated protein kinase (MAPK) signaling pathway, specifically the MEK5/ERK5 (extracellular signal-regulated kinase 5) cascade. MEK5 (MAPK/ERK kinase 5) is a dual-specificity kinase that phosphorylates and activates ERK5. a key regulator of cellular responses such as proliferation, differentiation, survival, and apoptosis. The MEK5-ERK5 pathway is distinct from other MAPK pathways (e.g., MEK1/2-ERK1/2) and is implicated in physiological processes like angiogenesis, cardiac development, and stress responses, as well as pathological conditions including cancer, cardiovascular diseases, and inflammation.

MEK5 antibodies are designed to detect MEK5 protein levels, phosphorylation status, or localization in various experimental models. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate MEK5 expression, activation, or interactions in cell lines, tissues, or disease models. Specificity and validation are critical, as cross-reactivity with other MAPK family members (e.g., MEK1/2) can occur. High-quality MEK5 antibodies are often validated using knockout or knockdown controls.

Research using MEK5 antibodies has revealed its role in tumor progression, chemoresistance, and endothelial cell regulation, making it a potential therapeutic target. However, challenges remain in understanding context-dependent signaling mechanisms and developing selective inhibitors, underscoring the continued importance of reliable MEK5-targeting reagents.

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