Rabbit Polyclonal TYK2(Ab-1054) Antibody

The TYK2 (Ab-1054) antibody is a research tool designed to target tyrosine kinase 2 (TYK2), a member of the Janus kinase (JAK) family involved in cytokine signaling. TYK2 plays a critical role in mediating immune responses by regulating pathways linked to interferons, IL-12. IL-23. and other cytokines. Dysregulation of TYK2 has been implicated in autoimmune diseases (e.g., psoriasis, lupus), inflammatory disorders, and certain cancers, making it a therapeutic target of interest. The Ab-1054 clone is commonly used in preclinical studies to detect TYK2 expression, assess its activation state, or inhibit its function in cellular and animal models. It is typically validated for applications like Western blotting, immunoprecipitation, and immunohistochemistry. Structurally, TYK2 contains four JAK homology (JH) domains, with the antibody often targeting regions critical for kinase activity or protein-protein interactions. Research using this antibody has contributed to understanding TYK2's role in signaling cascades, such as JAK-STAT, and its crosstalk with other pathways. Additionally, studies leveraging Ab-1054 have supported the development of selective TYK2 inhibitors, which aim to modulate immune responses while minimizing off-target effects associated with broader JAK inhibition.