| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAV; CAV1; |
| Entrez GeneID | 857; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于Caveolin-1(Ab-14)抗体的3篇参考文献示例(注：文献为虚构模拟，仅作格式参考)：
---
1. **文献名称**：*Caveolin-1 regulates endothelial cell survival via the PI3K/Akt pathway*
**作者**：Li S, et al.
**摘要**：本研究利用Caveolin-1(Ab-14)抗体进行Western blot和免疫荧光实验，证明Caveolin-1通过PI3K/Akt信号通路调控内皮细胞存活，为动脉粥样硬化治疗提供新靶点。
2. **文献名称**：*Role of Caveolin-1 in tumor progression and metastasis*
**作者**：Martinez-Outschoorn UE, et al.
**摘要**：通过Caveolin-1(Ab-14)抗体的免疫组化分析，发现Caveolin-1在乳腺癌中表达下调，其缺失与肿瘤微环境重塑及转移增强相关。
3. **文献名称**：*Caveolin-1 modulates TGF-β signaling in fibroblasts*
**作者**：Wang H, et al.
**摘要**：使用Caveolin-1(Ab-14)抗体进行共聚焦显微镜观察，证实Caveolin-1通过结合TGF-β受体抑制成纤维细胞活化，提示其在纤维化疾病中的保护作用。
---
**说明**：实际文献需通过PubMed、Google Scholar等平台检索关键词“Caveolin-1 antibody Ab-14”或相关研究领域(如信号通路、疾病模型)进行筛选。若Ab-14为某品牌抗体(如Santa Cruz产品)，可查阅厂商官网提供的参考文献列表。
Caveolin-1 (Ab-14) is a monoclonal antibody specifically targeting Caveolin-1. a key structural protein of caveolae, which are small invaginations in the plasma membrane involved in cellular signaling, lipid transport, and endocytosis. Caveolin-1 plays critical roles in membrane organization, vesicular trafficking, and regulation of signaling molecules such as G-proteins, receptor tyrosine kinases, and endothelial nitric oxide synthase (eNOS). It is expressed in multiple cell types, including endothelial cells, adipocytes, and fibroblasts, and is implicated in processes like cholesterol homeostasis, tumor suppression, and mechanotransduction.
The Ab-14 clone recognizes an epitope within the N-terminal region (amino acids 1-21) of human Caveolin-1. enabling detection of both the α (18 kDa) and β (21 kDa) isoforms. This antibody is widely used in applications such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study Caveolin-1 expression, localization, and function in normal and pathological contexts, including cancer, cardiovascular diseases, and metabolic disorders. Its specificity is validated through knockout controls or siRNA-mediated knockdown, showing minimal cross-reactivity with Caveolin-2 or Caveolin-3. Research utilizing this antibody has contributed to understanding caveolae-mediated signaling pathways and their roles in disease mechanisms, making it a valuable tool in cell biology and biomedical studies.
×
