| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FES, c-fes, FPS, Feline sarcoma oncogene, Proto-oncogene c-Fps, v-fps, p93c-fes, Proto-oncogene c-Fes, v-fes, v-fes feline sarcoma viral |
| Entrez GeneID | 2242; |
| WB Predicted band size | 93kDa. |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human c-Fes (Phospho-Tyr713) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于c-Fes (Phospho-Tyr713)抗体的参考文献示例(内容基于文献结构假设，非真实存在)：
1. **文献名称**：*"Phosphorylation of c-Fes at Tyr713 regulates its kinase activity in myeloid differentiation"*
**作者**：Smith A, et al.
**摘要**：研究利用Phospho-Tyr713抗体证实，c-Fes在髓系细胞分化中通过Tyr713磷酸化激活其激酶活性，促进STAT3信号通路，并调控细胞分化进程。
2. **文献名称**：*"Role of c-Fes tyrosine phosphorylation in breast cancer invasion"*
**作者**：Lee J, et al.
**摘要**：通过Western blot和免疫荧光分析，发现Phospho-Tyr713抗体检测到c-Fes在乳腺癌细胞中高磷酸化，与细胞迁移和侵袭能力增强相关，提示其作为转移标志物的潜力。
3. **文献名称**：*"c-Fes interacts with PI3K via phospho-Tyr713 to modulate cell survival signaling"*
**作者**：Hackenmiller R, et al.
**摘要**：研究使用Phospho-Tyr713抗体发现，磷酸化c-Fes与PI3K亚基p85结合，增强Akt通路活性，从而抑制造血细胞凋亡，揭示其在生存信号中的调控机制。
4. **文献名称**：*"Development and validation of a phospho-specific c-Fes (Y713) antibody for clinical diagnostics"*
**作者**：Chen L, et al.
**摘要**：报道了一种高特异性Phospho-Tyr713抗体的开发，验证其在结直肠癌组织中的检测效果，发现磷酸化水平与肿瘤分期和患者预后显著相关。
(注：以上为模拟内容，实际文献需通过PubMed等平台检索确认。)
The c-Fes (Phospho-Tyr713) antibody is a specialized tool used to detect the phosphorylated form of the c-Fes tyrosine kinase at tyrosine residue 713 (Y713). c-Fes, also known as FES or FPS, is a non-receptor protein tyrosine kinase involved in regulating cellular signaling pathways, including those related to cell differentiation, survival, and immune responses. Its activity is tightly controlled by phosphorylation events, with autophosphorylation at Y713 serving as a critical activation mechanism. This modification enhances kinase activity, enabling c-Fes to phosphorylate downstream substrates and mediate signaling cascades linked to cytoskeletal reorganization, hematopoietic cell development, and oncogenesis.
The c-Fes (Phospho-Tyr713) antibody is particularly valuable in research exploring kinase activation dynamics, especially in studies of cancer and hematologic malignancies where aberrant c-Fes signaling may contribute to disease progression. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation status in cell lines or tissue samples. Validated for specificity, this antibody helps elucidate the role of c-Fes in cellular contexts, such as its tumor-suppressive or oncogenic dual functions, depending on cellular environment and interaction partners. Its application aids in understanding disease mechanisms and potential therapeutic targeting of c-Fes-related pathways.
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