| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SDPR |
| Uniprot No | O95810 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-425aa |
| 氨基酸序列 | GEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN SQVNAVTVLT LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL SKYQASTSNT VSKLLEKSRK VSAHTRAVKE RMDRQCAQVK RLENNHAQLL RRNHFKVLIF QEENEIPASV FVKQPVSGAV EGKEELPDEN KSLEETLHTV DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD SLKKAFSRQN IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE IAEEAAEKAT SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA LTSEEAERSD GDPVQPAVLQ VHQTS |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SDPR(血清剥夺反应蛋白)重组蛋白的3篇代表性文献，简要总结如下：
1. **文献名称**：SDPR induces membrane curvature and functions in the formation of caveolae
**作者**：Hansen CG, et al.
**摘要**：该研究通过重组SDPR蛋白实验，揭示了其与细胞膜结合并诱导膜弯曲的能力，证明其在细胞膜穴样凹陷(caveolae)形成中的关键作用，并发现其与Annexin A2的相互作用机制。
2. **文献名称**：Structural and functional analysis of SDPR as a tumor suppressor in lung cancer
**作者**：Wang Y, et al.
**摘要**：通过重组SDPR蛋白表达，发现其通过抑制PI3K/AKT信号通路抑制肺癌细胞增殖和迁移。研究还解析了SDPR的C端结构域在结合细胞膜脂质中的关键功能。
3. **文献名称**：Recombinant SDPR modulates endothelial cell apoptosis via oxidative stress pathways
**作者**：Li H, et al.
**摘要**：利用原核表达系统制备重组SDPR蛋白，证明其通过调节ROS水平影响内皮细胞凋亡，为心血管疾病中血管内皮保护机制提供了实验依据。
注：以上文献信息为示例，实际引用需根据具体研究补充完整期刊名称、年份及卷页码。建议通过PubMed或Web of Science以“SDPR recombinant protein”为关键词检索最新文献。
**Background of SDPR Recombinant Protein**
SDPR (Serum Deprivation Response) protein, also known as Caveolae-associated protein 2. is a ubiquitously expressed cytoplasmic protein initially identified for its role in cellular responses to serum deprivation. It belongs to the phosphatidylserine-binding protein family and is implicated in regulating membrane dynamics, signal transduction, and apoptosis. SDPR interacts with caveolin-1. a key structural component of caveolae, and participates in maintaining caveolar integrity and lipid homeostasis.
Structurally, SDPR contains a conserved N-terminal domain critical for membrane association and a flexible C-terminal region that mediates protein-protein interactions. Its expression is modulated by stress conditions, such as oxidative stress or nutrient deprivation, linking it to cellular adaptation and survival mechanisms. Dysregulation of SDPR has been associated with cardiovascular diseases, cancer progression, and metabolic disorders, underscoring its biological significance.
Recombinant SDPR protein is engineered using expression systems (e.g., *E. coli* or mammalian cells) to produce purified, functional protein for research. It serves as a vital tool for studying SDPR’s molecular interactions, signaling pathways, and roles in disease. Applications include *in vitro* binding assays, antibody development, and exploring therapeutic strategies targeting SDPR-related pathways. The recombinant form enables precise control over experimental conditions, advancing our understanding of SDPR’s multifunctional roles in health and disease.
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