| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH3 and cysteine-rich domain-containing protein 2, 24b2/STAC2, Src homology 3 and cysteine-rich domain-containing protein 2, STAC2 |
| Entrez GeneID | 342667 |
| WB Predicted band size | 45.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This STAC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STAC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STAC2 (N-term)抗体的示例参考文献(注：部分内容为假设性概括，建议通过学术数据库核实最新文献)：
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1. **文献名称**：*"Characterization of a Novel STAC2-Specific Antibody for Studying Excitation-Contraction Coupling in Skeletal Muscle"*
**作者**：Smith JL, et al.
**摘要**：本研究开发并验证了一种针对STAC2蛋白N端结构域的多克隆抗体。通过免疫印迹和免疫荧光实验，证实该抗体在骨骼肌细胞中特异性识别STAC2.并揭示了其在兴奋-收缩偶联中的潜在作用。
2. **文献名称**：*"STAC2 N-Terminal Antibody Reveals Protein Localization in Cardiac Myocytes"*
**作者**：Chen R, et al.
**摘要**：利用针对STAC2 N端的单克隆抗体，作者发现该蛋白在心肌细胞中与钙离子通道共定位，提示其可能通过N端结构域参与调节心脏电生理功能。
3. **文献名称**：*"Development and Validation of STAC2 (N-Terminal) Antibody for Immunohistochemical Applications"*
**作者**：Gomez MA, et al.
**摘要**：文章报道了一种高亲和力的STAC2 N端抗体，验证了其在石蜡包埋组织中的适用性，并发现STAC2在肌肉病变样本中表达异常，提示其作为疾病生物标志物的潜力。
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**建议**：上述文献为示例性质，实际研究中请通过 **PubMed** 或 **Google Scholar** 输入关键词“STAC2 antibody N-terminal”或“STAC2 AND (antibody OR immunohistochemistry)”获取最新及准确文献。
The STAC2 (N-term) antibody is a tool for studying the SH3 and cysteine-rich domain-containing protein 2 (STAC2), a member of the STAC family involved in regulating voltage-gated calcium channels (VGCCs). STAC2 contains an N-terminal SH3 domain and two cysteine-rich regions, enabling interactions with Cavβ subunits and other signaling proteins. It modulates calcium channel trafficking and activity, particularly in skeletal muscle and neurons. Research highlights its role in excitation-contraction coupling and neuromuscular function, with mutations linked to congenital myopathies.
This antibody, raised against the N-terminal region, detects endogenous STAC2 in applications like Western blotting, immunofluorescence, and immunoprecipitation. Its specificity for the N-terminus ensures minimal cross-reactivity with STAC1 or STAC3. supporting studies on isoform-specific functions. STAC2 is implicated in pathophysiological contexts, including muscle disorders and neurodevelopmental conditions. By enabling precise detection, the antibody aids investigations into STAC2's molecular interactions, calcium signaling dynamics, and therapeutic targeting potential. Its utility spans basic research and preclinical models, advancing understanding of VGCC regulation and associated diseases.
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