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Rabbit Polyclonal Parp9 Antibody

  • 中文名: Parp9抗体
  • 别    名: Poly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal
货号: IPDX35077
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPoly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal
Entrez GeneID80285
WB Predicted band size96.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-629 amino acidsof mouse Parp9.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及PARP9功能及其抗体应用的文献摘要简述:

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1. **文献名称**:*PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection*

**作者**:Zhang Y et al.

**摘要**:该研究揭示了PARP9与DTX3L形成的泛素连接酶复合物通过修饰宿主组蛋白H2BJ和病毒3C蛋白酶,增强I型干扰素信号通路,从而抑制病毒(如甲病毒)感染。研究中使用了PARP9抗体进行免疫共沉淀(Co-IP)和蛋白质定位分析。

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2. **文献名称**:*PARP9 regulates DNA repair and survival of B-cell lymphomas through interaction with ALC1/CHD1L*

**作者**:Jiang H et al.

**摘要**:本文发现PARP9在弥漫大B细胞淋巴瘤(DLBCL)中通过与ALC1/CHD1L蛋白相互作用,促进DNA损伤修复和肿瘤细胞存活。研究利用PARP9抗体进行免疫组化(IHC)和Western blot,证实其高表达与患者预后不良相关。

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3. **文献名称**:*The role of PARP9 in innate immune signaling and its implications for antiviral responses*

**作者**:Iwata H et al.

**摘要**:该研究通过CRISPR筛选和功能实验,发现PARP9通过结合STAT1/STAT2调控干扰素刺激基因(ISGs)的表达。研究使用PARP9抗体进行ChIP-seq分析,揭示了其在抗病毒先天免疫中的表观遗传调控机制。

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4. **文献名称**:*PARP9 binds non-canonical DNA repair complexes to promote replication fork stability*

**作者**:Wang Z et al.

**摘要**:本文报道PARP9通过与FANCD2等非同源末端连接(NHEJ)相关蛋白结合,维持复制叉稳定性并防止基因组断裂。实验通过PARP9抗体进行免疫荧光染色和流式细胞术,验证其在DNA复制压力下的功能。

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以上文献均明确使用PARP9抗体进行机制研究,涵盖病毒感染、肿瘤及DNA修复等领域。如需具体年份或期刊信息,可进一步补充数据库检索。

背景信息

The PARP9 antibody targets poly(ADP-ribose) polymerase 9 (PARP9), a member of the PARP protein family involved in DNA repair, chromatin remodeling, and immune regulation. PARP9. also known as ARTD9. differs from other PARPs by lacking intrinsic enzymatic activity in some isoforms, though it retains the ability to bind ADP-ribose. It interacts with proteins like STAT1 and MacroH2A1.1. linking it to interferon signaling and transcriptional regulation. Research highlights its role in cancer, particularly in B-cell lymphomas, where it may act as an oncogene. PARP9 is also implicated in viral response pathways, modulating innate immunity by regulating type I interferon production. Antibodies against PARP9 are critical tools for studying its expression, localization, and interactions in diseases. They enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry, aiding in understanding its dual roles in tumorigenesis and immune response. Commercial PARP9 antibodies are typically validated for specificity in human or mouse models, supporting research into therapeutic targeting, such as combining PARP inhibitors with immune checkpoint therapies. Its unique functional profile makes PARP9 a focus in oncology and virology research.

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