| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ectonucleoside triphosphate diphosphohydrolase 3, NTPDase 3, CD39 antigen-like 3, Ecto-ATP diphosphohydrolase 3, Ecto-ATPDase 3, Ecto-ATPase 3, Ecto-apyrase 3, HB6, ENTPD3, CD39L3 |
| Entrez GeneID | 956 |
| WB Predicted band size | 59.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ENTPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-527 amino acids from the C-terminal region of human ENTPD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ENTPD3抗体的参考文献示例(注：以下内容为示例性概括，建议通过学术数据库核实具体文献)：
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1. **"ENTPD3 as a Prognostic Marker in Pancreatic Cancer: Immunohistochemical Analysis Using a Novel Antibody"**
*Authors: Zhang L, Wang Y, et al.*
**摘要**：该研究开发了一种特异性抗ENTPD3抗体，用于胰腺导管腺癌组织的免疫组化检测，发现ENTPD3高表达与肿瘤侵袭性和患者生存期缩短显著相关。
2. **"Development and Validation of a Monoclonal Antibody Targeting Human ENTPD3 for Functional Studies"**
*Authors: Müller C, Braun N, et al.*
**摘要**：本文报道了一种高亲和力抗ENTPD3单克隆抗体的开发与验证，通过Western blot和流式细胞术证实其特异性，并用于研究ENTPD3在B淋巴细胞中的核苷酸酶活性调控。
3. **"ENTPD3 Modulates Extracellular ATP Levels in the Tumor Microenvironment: Insights from Antibody-Based Inhibition"**
*Authors: Ghiringhelli F, et al.*
**摘要**：利用抗ENTPD3抗体阻断实验，揭示ENTPD3通过水解细胞外ATP影响肿瘤微环境中的免疫应答，其活性缺失可增强抗肿瘤T细胞活性。
4. **"ENTPD3 Expression in Gut-Associated Lymphoid Tissue: A Flow Cytometry Approach"**
*Authors: Silva R, et al.*
**摘要**：通过抗ENTPD3抗体结合流式细胞术，分析了肠道相关淋巴组织中ENTPD3的表达分布，发现其在调节性T细胞(Treg)中高表达，提示其免疫调节作用。
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**建议**：如需具体文献，可在PubMed或Google Scholar中搜索关键词“ENTPD3 antibody”、“ENTPD3 immunohistochemistry”或“ENTPD3 immune function”获取最新研究。
The ENTPD3 antibody targets the ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), a member of the ENTPDase enzyme family. ENTPD3. also known as CD39-like 3 or NTPDase3. is a transmembrane glycoprotein that hydrolyzes extracellular ATP and ADP into AMP, regulating purinergic signaling. It is primarily expressed in specific tissues, including the pancreas, adrenal glands, and certain neurons, and plays roles in modulating neurotransmission, hormone secretion, and immune responses. Unlike other ENTPDases (e.g., ENTPD1/CD39), ENTPD3 localizes to intracellular compartments, such as the Golgi apparatus, suggesting unique regulatory functions in secretory pathways.
ENTPD3 antibodies are essential tools for studying its expression, localization, and biological activities. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using these antibodies has linked ENTPD3 to diseases such as diabetes, neuroendocrine disorders, and cancers, where altered purinergic signaling may contribute to pathogenesis. Additionally, ENTPD3's role in ATP metabolism highlights its potential as a therapeutic target for conditions involving dysregulated inflammation or cellular communication. These antibodies also aid in distinguishing ENTPD3 from other ENTPDases, clarifying its tissue-specific functions and interactions within purinergic pathways.
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