Rabbit Polyclonal (DANRE)rx2(N-term) Antibody

The DANRE rx2 (N-term) antibody is a polyclonal antibody designed to target the N-terminal region of the Rx2 protein in *Danio rerio* (zebrafish). Rx2. a member of the retinal homeobox (Rx) family of transcription factors, plays a critical role in vertebrate eye development, particularly in the specification and maintenance of retinal progenitor cells during embryogenesis. In zebrafish, Rx2 is functionally redundant with Rx1 but is essential for proper optic vesicle patterning and photoreceptor differentiation. The antibody is commonly used in developmental biology research to study retinal development, gene expression dynamics, and protein localization in zebrafish models. It is validated for applications such as immunohistochemistry, Western blotting, and immunofluorescence, enabling visualization of Rx2 expression in embryonic tissues. The N-terminal specificity ensures recognition of full-length Rx2 while minimizing cross-reactivity with truncated isoforms or related proteins. Researchers often employ this antibody to investigate genetic or environmental disruptions in eye morphogenesis, offering insights into congenital ocular disorders. Its utility extends to comparative studies of Rx family evolution across vertebrates, given the conserved role of Rx proteins in eye development. Proper controls, including rx2-mutant zebrafish, are recommended to confirm antibody specificity in experimental setups.