| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A, RHOQ, ARHQ, RASL7A, TC10 |
| Entrez GeneID | 23433 |
| WB Predicted band size | 22.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-76 amino acids from the Central region of human TC10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3-4条关于TC10抗体的虚构参考文献示例(注：实际文献需通过学术数据库验证，以下内容为模拟生成)：
---
1. **文献名称**：*TC10 GTPase regulates insulin-stimulated GLUT4 translocation in adipocytes*
**作者**：Watson, R. et al.
**摘要**：本文利用TC10特异性抗体，通过免疫沉淀和Western blot技术，揭示了TC10在胰岛素信号通路中调控GLUT4囊泡向细胞膜转运的关键作用，证实其通过PI3K非依赖性途径影响葡萄糖摄取。
2. **文献名称**：*Role of TC10 in neuronal polarization and axon outgrowth*
**作者**：Chen, L. & Gomez, T.
**摘要**：通过TC10抗体的免疫荧光染色，研究发现TC10在神经元发育过程中调控微管动力学和生长锥导向，其活性依赖Cdc42上游信号，为神经再生研究提供新靶点。
3. **文献名称**：*TC10-mediated endocytosis in cancer cell migration*
**作者**：Sato, K. et al.
**摘要**：使用TC10抗体阻断实验表明，TC10通过激活N-WASP/Arp2/3复合物促进侵袭性乳腺癌细胞的膜皱褶形成和基质侵袭，提示其在转移中的潜在治疗价值。
4. **文献名称**：*Antibody-based profiling of TC10 expression in colorectal tissues*
**作者**：Müller, S. et al.
**摘要**：开发高特异性TC10单克隆抗体，用于组织微阵列分析，发现TC10在结直肠癌中表达显著上调，并与患者预后不良相关，支持其作为生物标志物的可能性。
---
**提示**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索(关键词：TC10 antibody、Rho family TC10、CDC42L7)。真实研究中，TC10抗体常用于检测蛋白表达、定位及功能研究，尤其在细胞动力学和疾病机制领域。
TC10 antibody targets the TC10 protein (also known as RhoQ or ARHQ), a member of the Rho GTPase family involved in regulating cytoskeletal dynamics, vesicular trafficking, and cellular signaling. Discovered in the late 1990s, TC10 is encoded by the *RHOQ* gene located on human chromosome 2p21. It shares structural homology with Cdc42 but exhibits distinct functional roles, particularly in insulin-stimulated glucose uptake via GLUT4 translocation in adipocytes and myocytes, linking it to metabolic disorders like diabetes. TC10 also participates in neurite outgrowth, cell polarization, and exocytosis pathways.
Antibodies against TC10 are widely used in research to study its spatial-temporal expression, activation states (GTP-bound vs. GDP-bound), and interactions with downstream effectors such as Exo70 and CIP4. These tools enable detection via techniques like Western blot, immunofluorescence, and immunoprecipitation. Commercial TC10 antibodies are typically raised in rabbits or mice, with validation in knockout models to ensure specificity. Dysregulation of TC10 has been implicated in cancer metastasis, neurological disorders, and metabolic syndromes, making its study clinically relevant. However, challenges remain in distinguishing isoform-specific functions due to overlapping roles with other Rho GTPases. Ongoing research aims to clarify its mechanistic contributions to disease and therapeutic potential.
×
