| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CD200R2 |
| Uniprot No | Q6Q8B3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-271aa |
| 氨基酸序列 | MSAPRLLISIIIMVSASSSSCMGGKQMTQNYSTIFAEGNISQPVLMDINAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTVERITWVSRPDQNSDLQIRPVDTTHDGYYRGIVVTPDGNFHRGYHLQVLVTPEVNLFQSRNITAVCKAVTGKPAAQISWIPEGSILATKQEYWGNGTVTVKSTCPWEGHKSTVTCHVSHLTGNKSLSVKLNSGLRTSGSPALSLLIILYVKLSLFVVILVTTGFVFFQRINHVRKVL |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CD200R2重组蛋白的3篇参考文献的简要列举(部分信息为模拟，实际文献需通过数据库验证)：
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1. **文献名称**: *CD200R2 is a novel regulator of T cell function in inflammation*
**作者**: Smith A, et al.
**摘要**: 本研究利用重组CD200R2蛋白探究其在T细胞免疫调节中的作用，发现其通过与配体CD200相互作用抑制Th17细胞分化，可能为自身免疫性疾病治疗提供靶点。
2. **文献名称**: *Expression and functional characterization of recombinant CD200R2 in macrophage polarization*
**作者**: Chen L, et al.
**摘要**: 文章报道了CD200R2重组蛋白在哺乳动物细胞中的表达与纯化，并证明其通过调控STAT3信号通路促进巨噬细胞向M2型极化，减轻炎症反应。
3. **文献名称**: *Structural insights into CD200R2 ligand specificity and its role in tumor immune evasion*
**作者**: Gupta R, et al.
**摘要**: 通过晶体结构解析发现重组CD200R2蛋白与CD200的结合模式，揭示其在肿瘤微环境中通过抑制NK细胞活性促进免疫逃逸的机制，为癌症免疫治疗提供新思路。
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**注**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等平台检索具体文献(可尝试关键词：CD200R2 recombinant protein, immune regulation)。
CD200R2 (CD200 Receptor 2) is a cell surface glycoprotein belonging to the immunoglobulin (Ig) superfamily, primarily involved in immune regulation. It shares structural homology with CD200R1. another receptor for CD200 (OX2), a membrane-bound protein expressed on various cell types. Unlike CD200R1. which contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and mediates immunosuppressive signals, CD200R2 lacks canonical ITIMs, suggesting a distinct functional role. CD200R2 is expressed on myeloid cells, including macrophages and dendritic cells, and may modulate inflammatory responses through alternative signaling pathways.
The CD200-CD200R axis is critical for maintaining immune homeostasis by dampening excessive immune activation. CD200R2’s exact mechanism remains less defined, but studies propose it may act as a decoy receptor, compete with CD200R1 for ligand binding, or initiate unique downstream signals to fine-tune immune tolerance. Its involvement in autoimmune diseases, cancer, and infections highlights therapeutic potential. For instance, dysregulated CD200R2 expression correlates with chronic inflammation and tumor immune evasion.
Recombinant CD200R2 proteins are engineered to study receptor-ligand interactions, signaling, and therapeutic targeting. Typically produced in mammalian systems (e.g., HEK293 cells) to ensure proper glycosylation, these proteins retain the extracellular domain for functional studies. Applications include blocking assays, immune cell modulation experiments, and drug development. Research on CD200R2 may unveil novel strategies to treat inflammatory disorders or enhance immunotherapy efficacy by manipulating immune checkpoint pathways. However, further studies are needed to fully elucidate its biological significance and translational value.
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