| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bone morphogenetic protein 8B, BMP-8, BMP-8B, Osteogenic protein 2, OP-2, BMP8B, BMP8 |
| Entrez GeneID | 656 |
| WB Predicted band size | 44.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This BMP8B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 332-364 amino acids from the human region of human BMP8B. |
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以下是关于BMP8B抗体的3篇代表性文献的模拟示例(注：内容为虚构，仅作参考格式演示)：
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1. **文献名称**: *BMP8B regulates thermogenic adipogenesis through antibody-targeted signaling pathways*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性BMP8B抗体，揭示了其在棕色脂肪细胞分化中的调控作用。通过Western blot和免疫荧光技术，证实BMP8B通过激活SMAD通路促进线粒体生物合成，为代谢性疾病治疗提供新靶点。
2. **文献名称**: *Development and validation of a monoclonal antibody for BMP8B detection in murine tissues*
**作者**: Chen L, et al.
**摘要**: 报道了一种高特异性抗小鼠BMP8B单克隆抗体的开发，通过ELISA和免疫组化验证其在多种组织(如睾丸和脂肪)中的检测效果，为BMP8B蛋白的定位研究提供可靠工具。
3. **文献名称**: *BMP8B antibody-based therapeutic potential in obesity-associated inflammation*
**作者**: García-Ruiz I, et al.
**摘要**: 研究使用中和性BMP8B抗体，证明其可抑制肥胖模型中脂肪组织的炎症反应，并通过阻断BMP8B与受体结合改善胰岛素抵抗，提示其作为抗炎治疗的潜在价值。
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**注意**：以上文献及内容为模拟生成，实际引用需查询PubMed、Web of Science等数据库获取真实研究。
The BMP8B antibody targets Bone Morphogenetic Protein 8B (BMP8B), a member of the TGF-β superfamily involved in regulating cellular processes such as differentiation, proliferation, and apoptosis. BMP8B plays critical roles in embryonic development, tissue homeostasis, and metabolic regulation, particularly in adipose tissue and reproductive systems. It is expressed in various tissues, including the brain, gonads, and adipose depots, where it modulates signaling pathways like SMAD-dependent cascades. Dysregulation of BMP8B has been linked to metabolic disorders, obesity, and infertility, highlighting its therapeutic and diagnostic potential.
BMP8B antibodies are essential tools for detecting and quantifying the protein in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically raised in hosts like rabbits or mice using immunogenic peptides or recombinant BMP8B fragments. Specificity validation via knockout controls or blocking assays is crucial to ensure reliability. Commercially available antibodies may vary in clonality (monoclonal/polyclonal), epitope recognition, and species reactivity (human, mouse, rat).
Current research leverages BMP8B antibodies to explore its role in metabolic syndrome, cancer progression, and reproductive health. For instance, studies suggest BMP8B enhances thermogenic adipocyte activity, making it a potential target for obesity therapies. In oncology, BMP8B may influence tumor microenvironment signaling. These antibodies thus serve as vital reagents for mechanistic studies and biomarker discovery.
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