| 纯度 | >90%SDS-PAGE. |
| 种属 | Mouse |
| 靶点 | IL11ra1 |
| Uniprot No | Q64385 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-432aa |
| 氨基酸序列 | MSSSCSGLTRVLVAVATALVSSSSPCPQAWGPPGVQYGQPGRPVMLCCPGVSAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQTLDGVSGGMVTLKLGFPPARPEVSCQAVDYENFSCTWSPGQVSGLPTRYLTSYRKKTLPGAESQRESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQSILRPDPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGLEEVITDAVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGPLQDEIPDWSQGHGQQLEAVVAQEDSPAPARPSLQPDPRPLDHRDPLEQVAVLASLGIFSCLGLAVGALALGLWLRLRRSGKDGPQKPGLLAPMIPVEKLPGIPNLQRTPENFS |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL11RA1重组蛋白的3篇参考文献，涵盖其功能、结构及潜在应用：
1. **文献名称**：*Interleukin-11 receptor signaling in the pathogenesis of inflammatory bowel disease*
**作者**：Britteno A, et al.
**摘要**：研究揭示了IL11RA1重组蛋白在肠道炎症中的作用，发现其通过激活下游STAT3通路加剧结肠炎模型中的组织纤维化，提示其作为治疗靶点的潜力。
2. **文献名称**：*Targeting IL11/IL11RA1 signaling inhibits proliferation and metastasis in solid tumors*
**作者**：Ng B, et al.
**摘要**：通过体外实验证明，IL11RA1重组蛋白阻断剂可抑制肿瘤细胞迁移和侵袭，并降低癌症模型中转移风险，为抗肿瘤治疗提供新策略。
3. **文献名称**：*Structural basis of IL-11 recognition by IL-11RA and gp130 receptor complex*
**作者**：Zhang Y, et al.
**摘要**：利用冷冻电镜解析IL11RA1与IL-11及gp130的三元复合物结构，阐明受体激活机制，为设计靶向IL11信号通路的小分子药物奠定基础。
(注：以上文献为虚拟示例，实际研究中建议通过PubMed或Google Scholar检索最新论文。)
Interleukin-11 receptor alpha 1 (IL11RA1) is a key component of the interleukin-11 (IL-11) receptor complex, which mediates signaling of the cytokine IL-11. This transmembrane protein belongs to the type I cytokine receptor family and shares structural homology with other IL-6 receptor family members. IL11RA1 pairs with glycoprotein 130 (gp130) to form a functional receptor capable of activating downstream signaling pathways, including JAK/STAT, MAPK, and PI3K, upon IL-11 binding.
Recombinant IL11RA1 protein is engineered to mimic the extracellular domain of the native receptor, often produced in mammalian or bacterial expression systems with purification tags (e.g., His-tag) for research applications. Its production enables studies of IL-11/IL11RA1 interactions, receptor activation mechanisms, and competitive inhibition experiments. Dysregulation of IL-11 signaling is implicated in pathological conditions such as fibrosis, inflammatory diseases, osteoporosis, and cancer progression, making recombinant IL11RA1 a valuable tool for investigating therapeutic interventions.
Notably, IL11RA1's role in tissue homeostasis and repair has spurred interest in its soluble form (sIL11RA), which may act as a decoy receptor to modulate IL-11 activity. Studies using recombinant IL11RA1 have clarified its tissue-specific functions, including its contribution to hematopoietic stem cell regulation, bone metabolism, and epithelial cell survival. Emerging evidence also links IL11RA1 mutations to craniofacial developmental disorders like Crouzon syndrome, highlighting its importance in skeletal development. As IL-11 targeting therapies gain traction, recombinant IL11RA1 remains critical for drug screening, structural studies, and elucidating disease mechanisms.
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