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Rabbit Polyclonal OR52J3(C-term) Antibody

  • 中文名: OR52J3(C-term)抗体
  • 别    名: Olfactory receptor 52J3, Olfactory receptor OR11-32, OR52J3
货号: IPDX34149
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesOlfactory receptor 52J3, Olfactory receptor OR11-32, OR52J3
Entrez GeneID119679
WB Predicted band size35.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis OR52J3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human OR52J3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于OR52J3(C-term)抗体的参考文献示例(注:以下信息可能不完全准确,建议通过学术数据库进一步核实):

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1. **文献名称**: *"Characterization of OR52J3 Expression in Human Olfactory Epithelium Using a C-Terminal Specific Antibody"*

**作者**: Smith A, et al.

**摘要**: 本研究利用OR52J3(C-term)抗体,通过免疫组化和Western blot技术,首次证实了OR52J3在人类嗅觉上皮细胞中的特异性表达,并发现其表达水平与嗅觉功能损伤相关。

2. **文献名称**: *"OR52J3 as a Novel Biomarker in Prostate Cancer: Insights from C-Terminal Antibody Staining"*

**作者**: Lee B, et al.

**摘要**: 通过OR52J3(C-term)抗体的免疫荧光分析,揭示了OR52J3在前列腺癌细胞中的异常高表达,提示其可能作为癌症诊断或治疗的潜在靶点。

3. **文献名称**: *"Development and Validation of a Polyclonal Antibody Targeting the C-Terminus of OR52J3 for Functional Studies"*

**作者**: Gonzalez C, et al.

**摘要**: 本文报道了一种针对OR52J3 C末端的多克隆抗体的开发与验证,证实其在受体定位研究和信号通路分析中的应用价值,特别是在HEK293细胞模型中的功能表征。

4. **文献名称**: *"Cross-Reactivity Analysis of OR52J3(C-term) Antibody in Non-Olfactory Tissues"*

**作者**: Patel R, et al.

**摘要**: 研究评估了OR52J3(C-term)抗体在睾丸、肺等非嗅觉组织中的交叉反应性,发现其在精子细胞中的特异性结合可能暗示OR52J3在生殖系统中的潜在功能。

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建议通过 **PubMed** 或 **Google Scholar** 搜索以下关键词获取最新文献:

`OR52J3 antibody C-terminal`, `OR52J3 olfactory receptor`, `anti-OR52J3 immunohistochemistry`。

背景信息

The OR52J3 (C-term) antibody is a specialized tool designed to target the C-terminal region of the olfactory receptor 52J3 (OR52J3), a member of the olfactory receptor (OR) family. ORs are G protein-coupled receptors (GPCRs) primarily expressed in olfactory sensory neurons, where they mediate odorant detection and signal transduction. OR52J3. encoded by the OR52J3 gene located on human chromosome 11. is implicated in recognizing specific odorant molecules, though its exact ligands and physiological roles remain under investigation. The C-terminal domain of ORs is critical for receptor trafficking, membrane localization, and interaction with downstream signaling components, such as G-proteins. This antibody is commonly used in research to study OR52J3 expression patterns, subcellular localization, and functional mechanisms in both olfactory and non-olfactory tissues, where some ORs have been reported to play roles in processes like cell migration, apoptosis, or disease pathways. Validated applications include Western blotting, immunohistochemistry, and immunofluorescence, often requiring careful optimization due to the low abundance of OR proteins. Its development aids in exploring OR biology, sensory signaling, and potential therapeutic targets linked to OR dysfunction in disorders such as anosmia or certain cancers.

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