Rabbit Polyclonal DNAJC5G Antibody

The DNAJC5G antibody targets the protein encoded by the DNAJC5G gene, a member of the DNAJ/HSP40 family. This family is characterized by conserved J-domain proteins that regulate molecular chaperones like HSP70. assisting in protein folding, disaggregation, and degradation. DNAJC5G, also called CSPgamma, shares structural homology with CSPα (DNAJC5), a synaptic vesicle protein implicated in neuronal maintenance and neurodegenerative diseases. However, DNAJC5G's precise biological roles remain less defined. It is broadly expressed in tissues, including the brain, and may participate in protein quality control or membrane trafficking. Research using DNAJC5G antibodies focuses on elucidating its localization, interaction partners, and potential links to pathologies. For instance, aberrant DNAJC5G expression has been observed in certain cancers and neurological disorders, suggesting possible diagnostic or therapeutic relevance. Antibodies against DNAJC5G enable detection via Western blot, immunohistochemistry, or immunofluorescence, aiding in functional studies. Current investigations aim to clarify its physiological mechanisms and explore its association with diseases like melanoma or lysosomal storage disorders, where disrupted protein homeostasis is a hallmark. Further work is needed to validate its specific roles and therapeutic potential.