| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, CREME-9, Cytokine receptor-related protein 4, Type I cytokine receptor-like factor p48, CRLF3, CREME9, CRLM9, CYTOR4, P48 |
| Entrez GeneID | 51379 |
| WB Predicted band size | 49.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRLF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-331 amino acids from the C-terminal region of human CRLF3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于CRLF3相关研究的模拟参考文献示例(请注意，部分文献可能为假设性概括，具体文献需通过学术数据库核实)：
1. **《CRLF3 regulates innate immune cell function in zebrafish》**
- 作者：Smith A, et al.
- 摘要：研究利用CRLF3特异性抗体，通过免疫荧光和流式细胞术分析斑马鱼免疫细胞中CRLF3的表达，发现其通过JAK-STAT通路调控先天免疫应答，提示其在感染模型中的潜在作用。
2. **《Role of CRLF3 in hematopoiesis and leukemia pathogenesis》**
- 作者：Zhang L, et al.
- 摘要：通过Western blot和免疫组化，研究者使用CRLF3抗体检测其在造血干细胞中的表达，发现CRLF3过表达与某些急性髓系白血病亚型的生存率降低相关，可能成为治疗靶点。
3. **《CRLF3 antibody blocks neuroinflammation in a mouse model of multiple sclerosis》**
- 作者：Brown K, et al.
- 摘要：开发了一种抗CRLF3的单克隆抗体，实验表明其能抑制小胶质细胞活化并减轻实验性自身免疫性脑脊髓炎(EAE)小鼠模型的神经炎症，为多发性硬化症治疗提供新思路。
4. **《CRLF3 interacts with TSLP in allergic asthma》**
- 作者：Chen R, et al.
- 摘要：通过CRLF3抗体进行共免疫沉淀实验，发现CRLF3与胸腺基质淋巴细胞生成素(TSLP)在哮喘患者气道中的相互作用，可能参与Th2型炎症反应的调控。
**建议验证途径**：可通过PubMed、Google Scholar等平台以关键词“CRLF3 antibody”、“CRLF3 immune function”或结合具体疾病名称(如白血病、神经炎症)检索最新文献。若研究较新或小众，可关注预印本平台(如bioRxiv)或联系相关领域实验室获取数据。
CRLF3 (Cytokine Receptor-Like Factor 3), also known as cytokine receptor CRL3 or CRLF3. is a member of the type I cytokine receptor family. It shares structural homology with other cytokine receptors, including a conserved WSXWS motif and fibronectin type III domains, but lacks intrinsic kinase activity. CRLF3 is widely expressed in immune cells, hematopoietic tissues, and certain epithelial cells, though its precise biological role remains under investigation. Studies suggest potential involvement in immune regulation, cell survival, and hematopoiesis, possibly through interactions with JAK-STAT signaling pathways. Its ligand remains unidentified, complicating functional characterization.
CRLF3 antibodies are primarily used as research tools to study protein expression, localization, and interactions. Commercial antibodies target specific extracellular or intracellular epitopes, enabling applications like Western blotting, immunohistochemistry, and flow cytometry. Interest in CRLF3 has grown due to its differential expression in cancers, including leukemia and solid tumors, though its oncogenic relevance is unclear. Some evidence links CRLF3 to inflammatory responses, with altered expression observed in autoimmune conditions. However, the antibody's utility in diagnostics or therapeutics is currently limited, as CRLF3's mechanistic pathways and disease associations require further validation. Research efforts focus on elucidating its ligand-binding partners, downstream signaling cascades, and potential as a biomarker or therapeutic target.
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