| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CKSHS2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CKS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GNG12抗体的3篇参考文献(内容基于真实研究概括，但文献标题和作者为虚拟示例，仅供参考)：
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1. **标题**: *GNG12 promotes tumor progression in colorectal cancer via MAPK signaling*
**作者**: Li X, et al.
**摘要**: 本研究通过免疫组化(使用GNG12特异性抗体)发现GNG12在结直肠癌组织中高表达，且与患者预后不良相关。机制研究表明GNG12通过激活MAPK通路促进肿瘤侵袭。
2. **标题**: *GNG12 regulates neuronal development through synaptic protein interactions*
**作者**: Smith J, et al.
**摘要**: 利用GNG12抗体进行Western blot和免疫荧光分析，发现GNG12在小鼠海马神经元中高表达，其缺失导致突触蛋白异常聚集，提示其在神经发育中的关键作用。
3. **标题**: *Development of a monoclonal antibody against GNG12 for diagnostic applications*
**作者**: Chen Y, et al.
**摘要**: 研究团队开发了一种高特异性抗GNG12单克隆抗体，验证其在乳腺癌和肺癌组织中的诊断潜力，并通过ELISA和免疫组化证实其灵敏度和稳定性。
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**备注**：以上文献为示例性质，实际研究中建议通过PubMed或Google Scholar以关键词“GNG12 antibody”或“G protein gamma 12”检索最新文献，并关注抗体开发、疾病机制或诊断应用相关研究。
The GNG12 antibody targets the gamma subunit of heterotrimeric G proteins encoded by the *GNG12* gene, which plays a critical role in G protein-coupled receptor (GPCR) signaling. GPCRs regulate diverse cellular processes, including proliferation, differentiation, and apoptosis, by transmitting extracellular signals via intracellular G proteins. GNG12. a member of the Gγ protein family, forms complexes with Gβ subunits to modulate downstream effector pathways. Dysregulation of GNG12 has been implicated in cancer, where it may act as a tumor suppressor or oncogene depending on context. For example, *GNG12* is frequently downregulated in glioblastoma and lung adenocarcinoma, correlating with poor prognosis, while its overexpression in colorectal cancer promotes Wnt/β-catenin signaling.
GNG12 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological states. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines. Research applications include investigating GPCR-related mechanisms, cancer biology, and potential therapeutic targets. Commercial GNG12 antibodies are typically validated for specificity and sensitivity, though variability may exist depending on epitope regions or isoforms. Continued studies on GNG12 could unveil novel insights into disease pathways and precision medicine strategies.
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