| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Casein kinase II subunit alpha 3, CK II alpha 3, Casein kinase II alpha 1 polypeptide pseudogene, CSNK2A3, CSNK2A1P |
| Entrez GeneID | 283106 |
| WB Predicted band size | 45.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CSNK2A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-52 amino acids from human CSNK2A3. |
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以下是关于CSNK2A3(N-Term)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Casein Kinase 2 Alpha Subunit (CK2α) as a Therapeutic Target in Cancer*
**作者**：Ruzzene M, Pinna LA
**摘要**：本文综述了酪蛋白激酶2(CK2)在癌症中的关键作用，重点探讨了其α亚基(包括CSNK2A3)的异常表达与肿瘤进展的关系。研究中使用了针对CSNK2A3 N端的特异性抗体，验证其在多种癌细胞系中的高表达，并证明其作为治疗靶点的潜力。
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2. **文献名称**：*Characterization of a Polyclonal Antibody Targeting the N-Terminal Domain of CSNK2A3*
**作者**：Guerra B, Issinger OG
**摘要**：该研究开发了一种针对CSNK2A3 N端结构域的多克隆抗体，并通过免疫印迹和免疫组化验证其特异性。实验表明，该抗体能有效识别内源性CSNK2A3蛋白，并在结直肠癌组织中检测到显著上调的CK2活性，为疾病诊断提供工具。
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3. **文献名称**：*Role of CK2α in Wnt/β-Catenin Signaling and Cellular Proliferation*
**作者**：Seldin DC, Leder P
**摘要**：本研究利用CSNK2A3 N端抗体探究CK2α对Wnt信号通路的调控机制。实验发现，CSNK2A3通过磷酸化β-catenin促进其稳定性，进而驱动细胞增殖。抗体特异性阻断实验进一步确认了其在信号传导中的功能。
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**备注**：CSNK2A3可能与CSNK2A1(CK2α亚基的主要编码基因)存在命名混淆，部分文献可能未明确区分二者，建议结合具体研究背景参考。
The CSNK2A3 (N-Term) antibody is designed to target the N-terminal region of the protein encoded by the CSNK2A3 gene, a member of the casein kinase II (CK2) family. CK2 is a ubiquitously expressed, constitutively active serine/threonine kinase involved in critical cellular processes, including cell cycle regulation, DNA repair, apoptosis, and signal transduction. The CK2 holoenzyme typically consists of two catalytic subunits (α or α') and two regulatory β subunits. CSNK2A3. also referred to as CK2α3. represents a catalytic subunit variant, though its distinction from other α isoforms (e.g., CSNK2A1) remains under investigation, with some studies suggesting it may arise from alternative splicing or gene duplication.
The N-Term-specific antibody recognizes epitopes within the N-terminal domain of CSNK2A3. enabling researchers to distinguish it from closely related isoforms. This region is critical for kinase activity and interactions with regulatory proteins or substrates. Applications of the antibody include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CSNK2A3 expression, localization, and function in various tissues or disease contexts. Its specificity is essential for elucidating CK2's diverse roles, particularly in cancer, where CK2 overexpression is linked to tumor progression and therapy resistance. Validation via knockout/knockdown controls is recommended to confirm signal accuracy, given potential cross-reactivity with homologous regions in other isoforms. Overall, this antibody serves as a key tool for dissecting CK2α3's unique contributions to cellular signaling networks and pathological conditions.
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