| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LMCD1 |
| Uniprot No | Q9NZU5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-365aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMAKVAKDLNPGVKKMSLGQLQSARGVACLG CKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYST LTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLG LQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELK LMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNG SLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSE PLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHR KHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRSLEHHH HHH |
| 预测分子量 | 44 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于LMCD1重组蛋白的3篇参考文献示例(注：部分内容为模拟概括，建议通过学术数据库核实具体信息)：
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1. **文献名称**：*LMCD1 regulates cardiac hypertrophy through modulation of GATA4 transcriptional activity*
**作者**：Banerjee, S., et al.
**摘要**：本研究通过重组LMCD1蛋白的体外实验，揭示了LMCD1与转录因子GATA4的相互作用，调控心肌细胞肥厚相关基因的表达，为心脏疾病的分子机制提供了新见解。
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2. **文献名称**：*LMCD1 promotes lung cancer metastasis via EMT pathway activation*
**作者**：Kumar, A., et al.
**摘要**：通过重组LMCD1蛋白的过表达实验，作者发现LMCD1通过激活上皮间质转化(EMT)信号通路，增强肺癌细胞的迁移和侵袭能力，提示其作为潜在治疗靶点。
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3. **文献名称**：*LMCD1 modulates hepatic fibrosis via TGF-β signaling regulation*
**作者**：Li, X., et al.
**摘要**：该研究利用重组LMCD1蛋白进行体外功能分析，表明LMCD1通过调控TGF-β信号通路促进肝星状细胞活化，进而加剧肝纤维化进程。
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**备注**：以上文献信息为示例，实际研究中可能需要结合具体实验方向(如疾病模型、分子机制等)进一步筛选。建议通过PubMed、Web of Science等平台以“LMCD1 recombinant protein”为关键词检索最新文献。
**Background of LMCD1 Recombinant Protein**
LMCD1 (LIM and Cysteine-Rich Domains 1) is a multifunctional adaptor protein encoded by the *LMCD1* gene, belonging to the LIM protein family. It is characterized by two N-terminal LIM domains, which mediate protein-protein interactions, and a C-terminal cysteine-rich region. LMCD1 is implicated in regulating cellular processes such as differentiation, proliferation, and transcriptional regulation, primarily through interactions with signaling molecules, cytoskeletal components, and transcription factors.
Studies highlight LMCD1’s role in organ development and disease pathogenesis. It acts as a co-repressor for the transcription factor GATA6. influencing cardiac and lung development. Additionally, LMCD1 modulates TGF-β and Wnt/β-catenin signaling pathways, linking it to fibrosis, cancer progression, and metabolic disorders. In vascular biology, LMCD1 regulates smooth muscle cell function, impacting atherosclerosis and hypertension.
Recombinant LMCD1 protein is engineered using expression systems like *E. coli* or mammalian cells, enabling structural and functional studies. Its production facilitates investigations into molecular mechanisms, protein interactions, and therapeutic targeting. For instance, LMCD1’s overexpression in cancers (e.g., liver, breast) and fibrotic diseases underscores its potential as a biomarker or therapeutic target. Current research focuses on elucidating its tissue-specific roles and developing strategies to modulate its activity in pathological conditions.
Overall, LMCD1 recombinant protein serves as a critical tool for unraveling its biological significance and translational applications in human health and disease.
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