Rabbit Polyclonal ATXN2(N-Term) Antibody

The ATXN2 (N-Term) antibody is a crucial tool for studying the ATXN2 protein, encoded by the ATXN2 gene, which plays roles in RNA metabolism, translational regulation, and cellular stress responses. ATXN2 contains a polyglutamine (polyQ) tract near its C-terminus; however, the N-terminal region is targeted by this antibody, allowing specific detection of the full-length protein or its isoforms. Mutations in ATXN2. particularly abnormal CAG repeat expansions in the polyQ region, are linked to spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS). The N-Term antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ATXN2 expression, localization, and interactions in normal and disease states. Research highlights its involvement in neuronal function, RNA-binding activities, and pathological aggregation in neurodegenerative diseases. Additionally, ATXN2’s interaction with proteins like TDP-43 and FUS underscores its relevance in ALS pathogenesis. This antibody aids in elucidating mechanisms of polyQ expansion toxicity, RNA dysregulation, and potential therapeutic targets, making it vital for both basic and clinical neuroscience studies.