Rabbit Polyclonal (DANRE)s1pr2(N-Term) Antibody

The DANRE s1pr2 (N-Term) antibody is designed to target the N-terminal region of the Sphingosine-1-phosphate receptor 2 (S1PR2) in *Danio rerio* (zebrafish). S1PR2. a G protein-coupled receptor, binds sphingosine-1-phosphate (S1P) and plays critical roles in embryonic development, vascular system formation, and cellular processes like migration and proliferation. In zebrafish models, S1PR2 is particularly studied for its involvement in cardiovascular development, neurogenesis, and immune response regulation. The N-terminal domain of S1PR2 contributes to ligand binding specificity and receptor activation, making it a key target for functional studies. This antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect S1PR2 expression and localization in zebrafish tissues. Its application aids in exploring mechanisms underlying angiogenesis, neural crest cell migration, and tissue repair. As zebrafish share conserved signaling pathways with mammals, findings using this antibody may provide insights into human diseases linked to S1PR2 dysregulation, including cancer, fibrosis, and inflammatory disorders. Validation typically includes testing in S1PR2-deficient models to confirm specificity. Researchers prioritize this antibody for its ability to elucidate S1PR2's spatiotemporal dynamics in developmental and pathological contexts.