| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity protein kinase CLK2, CDC-like kinase 2, Clk2 |
| Entrez GeneID | 12748 |
| WB Predicted band size | 60.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Clk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the N-terminal region of mouse Clk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Clk2 (N-term)抗体的3篇假设性参考文献示例(注：内容为模拟，实际文献需通过数据库检索确认)：
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1. **文献名称**：*"CLK2 regulates hepatic insulin sensitivity through phosphorylation of FOXO1"*
**作者**：Smith A, et al.
**摘要**：利用小鼠Clk2 (N-term)抗体进行Western blot和免疫组化，证实CLK2通过磷酸化FOXO1调控肝脏胰岛素信号通路，影响糖代谢。
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2. **文献名称**：*"A kinase-deficient variant of Clk2 promotes alternative splicing via interaction with SF3B1"*
**作者**：Lee JH, et al.
**摘要**：通过免疫共沉淀(使用N端特异性Clk2抗体)发现CLK2激酶活性缺失突变体与剪接因子SF3B1结合，改变RNA选择性剪接，影响细胞分化。
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3. **文献名称**：*"Temporal expression profiling of Clk2 in mouse embryonic development"*
**作者**：Garcia R, et al.
**摘要**：采用Clk2 (N-term)抗体进行组织特异性分析，揭示CLK2在小鼠胚胎早期神经管和心脏发育中高表达，提示其参与器官形成调控。
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4. **文献名称**：*"CLK2-dependent phosphorylation of Drp1 promotes mitochondrial fission in neurons"*
**作者**：Chen X, et al.
**摘要**：通过N端抗体抑制CLK2活性，证明其磷酸化Drp1并驱动线粒体分裂，影响神经元能量代谢与凋亡过程。
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(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词“CLK2 antibody”、“CDC-like kinase 2 N-terminal”等验证。)
The Mouse Clk2 (N-term) antibody is a polyclonal antibody designed to detect the N-terminal region of CDC-like kinase 2 (Clk2), a serine/threonine kinase belonging to the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. Clk2 plays a regulatory role in RNA splicing, cell cycle progression, and stress response by phosphorylating serine/arginine-rich (SR) proteins, which are critical for mRNA processing and nuclear export. This antibody is commonly used in applications such as Western blotting, immunohistochemistry, and immunofluorescence to study Clk2 expression and localization in mouse tissues or cell lines.
Clk2 is implicated in diverse cellular processes, including apoptosis, differentiation, and metabolic regulation. Dysregulation of Clk2 has been linked to pathologies such as cancer, neurodegenerative disorders, and diabetes, making it a target for therapeutic research. The N-terminal specificity of this antibody ensures recognition of full-length or truncated Clk2 isoforms, aiding in studies of its functional domains and post-translational modifications. Validated for specificity and sensitivity, the antibody is a key tool for elucidating Clk2's role in cellular signaling networks and disease mechanisms. Researchers often employ it alongside kinase activity assays or RNAi-based approaches to explore Clk2's biological relevance.
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