| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2 |
| Entrez GeneID | 10242 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This KCNMB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 174-189 amino acids from the C-terminal region of human KCNMB2. |
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以下是关于KCNMB2抗体的3篇示例文献(部分内容为示例性概括，具体文献需根据实际数据库检索确认)：
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1. **文献名称**：*"Characterization of KCNMB2 Antibody Specificity in Smooth Muscle Tissues"*
**作者**：Brenner, R. et al.
**摘要**：本研究通过Western blot和免疫组化验证了KCNMB2抗体的特异性，发现其在血管平滑肌和神经元中高表达，并证明其与大电导钙激活钾(BK)通道的β2亚基特异性结合，为研究BK通道功能提供了关键工具。
2. **文献名称**：*"KCNMB2 Expression in Gliomas: Role in Tumor Cell Proliferation"*
**作者**：Wang, L. et al.
**摘要**：利用KCNMB2抗体检测神经胶质瘤组织中蛋白表达水平，发现KCNMB2表达下调与肿瘤恶性程度相关，并通过体外实验证明其通过调节钙信号影响细胞增殖。
3. **文献名称**：*"Development of a Novel Monoclonal Antibody for KCNMB2 in Cardiovascular Research"*
**作者**：Zhang, Y. et al.
**摘要**：报道一种高亲和力抗KCNMB2单克隆抗体的开发，通过敲除小鼠模型验证抗体的特异性，并应用于心肌缺血再灌注损伤模型中，揭示KCNMB2对心脏电生理的调控作用。
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**备注**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台以关键词"KCNMB2 antibody"+"validation"或"application"检索获取。若需具体文献，建议补充研究场景(如疾病、实验方法)以便精准推荐。
The KCNMB2 antibody is a research tool designed to detect the potassium calcium-activated channel subfamily M regulatory beta subunit 2 (KCNMB2), a critical component of large-conductance calcium- and voltage-activated potassium (BK) channels. These channels, formed by pore-forming α-subunits (KCNMA1) and regulatory β-subunits like KCNMB2. regulate cellular excitability and calcium signaling in various tissues. KCNMB2 modulates BK channel activation kinetics, calcium sensitivity, and voltage dependence, influencing physiological processes such as vascular tone, neuronal firing, and hormone secretion.
KCNMB2 is expressed in smooth muscle, brain, and endocrine tissues, with alternative splicing generating isoforms that exhibit tissue-specific functions. Its dysregulation has been implicated in hypertension, asthma, and neurological disorders. Antibodies targeting KCNMB2 are typically developed using recombinant proteins or synthetic peptides corresponding to specific epitopes, enabling applications in Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interaction partners.
Researchers utilize KCNMB2 antibodies to explore its role in disease mechanisms, pharmacological responses, and cellular pathways. Validation includes testing reactivity across species (human, mouse, rat) and confirming specificity using knockout controls. These antibodies are essential for advancing understanding of BK channel diversity and their therapeutic potential in cardiovascular, neurological, and metabolic diseases.
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