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Rabbit Polyclonal BTG4 Antibody

  • 中文名: BTG4抗体
  • 别    名: Protein BTG4, BTG family member 4, Protein PC3b, BTG4, PC3B
货号: IPDX33046
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein BTG4, BTG family member 4, Protein PC3b, BTG4, PC3B
Entrez GeneID54766
WB Predicted band size26.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis BTG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the C-terminal region of human BTG4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于BTG4抗体的假设性参考文献示例(请注意,以下内容为虚构,仅用于示例格式):

1. **文献名称**: "BTG4 as a biomarker in ovarian insufficiency: Expression analysis using a novel monoclonal antibody"

**作者**: Li X, et al.

**摘要**: 研究通过开发特异性BTG4单克隆抗体,发现BTG4在卵巢颗粒细胞中的表达降低与卵巢早衰相关,提示其作为诊断标志物的潜力。

2. **文献名称**: "Prognostic significance of BTG4 in colorectal cancer: Immunohistochemical study"

**作者**: Wang Y, et al.

**摘要**: 利用BTG4抗体进行免疫组化分析,发现BTG4低表达与结直肠癌患者生存期缩短显著相关,表明其可能作为肿瘤抑制因子。

3. **文献名称**: "BTG4 regulates maternal mRNA decay during oocyte maturation via interaction with CCR4-NOT complex"

**作者**: Chen R, et al.

**摘要**: 通过BTG4抗体的Western blot和免疫共沉淀实验,揭示了BTG4通过招募CCR4-NOT复合体调控卵母细胞中母源mRNA的降解,影响胚胎发育。

4. **文献名称**: "Development and validation of a BTG4-specific polyclonal antibody for functional studies in mammalian cells"

**作者**: Gupta S, et al.

**摘要**: 报道了一种高特异性BTG4多克隆抗体的开发,验证其在流式细胞术和免疫荧光中的应用,并证实BTG4在细胞周期阻滞中的功能。

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注:以上文献为示例,实际研究中请通过PubMed、Google Scholar等平台检索真实文献。

背景信息

The BTG4 antibody is a research tool used to detect and study the B-cell translocation gene 4 (BTG4) protein, a member of the BTG/Tob family involved in regulating cellular processes like proliferation, differentiation, and stress responses. BTG4 is notably expressed in germ cells and plays a critical role in reproductive biology, particularly in oocyte maturation and maternal mRNA degradation during early embryogenesis. It interacts with components of the CCR4-NOT deadenylase complex, contributing to mRNA decay and translational control. Dysregulation of BTG4 has been linked to reproductive disorders, including premature ovarian insufficiency and embryonic developmental defects. In cancer research, BTG4 is suggested to act as a tumor suppressor, with reduced expression observed in certain malignancies. The BTG4 antibody enables researchers to investigate its expression patterns, subcellular localization, and interactions in various biological contexts through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications span reproductive biology, developmental studies, and oncology, offering insights into molecular mechanisms underlying fertility and carcinogenesis. Validation of BTG4 antibody specificity remains crucial, as cross-reactivity with other BTG family members may occur depending on epitope design.

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