| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-lactalbumin, Lactose synthase B protein, Lysozyme-like protein 7, LALBA, LYZL7 |
| Entrez GeneID | 3906 |
| WB Predicted band size | 16.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LALBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human LALBA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LALBA(α-乳白蛋白)抗体的模拟参考文献示例(注：内容为虚构，仅供格式参考)：
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1. **文献名称**：*Development of a Monoclonal Antibody for Sensitive Detection of Bovine Alpha-Lactalbumin in Dairy Products*
**作者**：Smith, J.R., et al.
**摘要**：本研究开发了一种针对牛源α-乳白蛋白(LALBA)的高特异性单克隆抗体，通过ELISA和Western blot验证其灵敏度与交叉反应性。该抗体可用于乳制品中LALBA的痕量检测，为乳蛋白过敏原分析提供了新工具。
2. **文献名称**：*Structural Insights into Human Alpha-Lactalbumin via Epitope Mapping Using Polyclonal Antibodies*
**作者**：Zhang, L., & Wang, H.
**摘要**：通过多克隆抗体表位定位技术，揭示了人源LALBA的关键构象域。研究发现抗体结合区域与乳糖合成酶活性位点重叠，为理解LALBA的功能机制及过敏原性提供了结构基础。
3. **文献名称**：*Alpha-Lactalbumin-Specific IgA Antibodies in Human Breast Milk: Correlation with Infant Gut Microbiota*
**作者**：Johnson, M.K., et al.
**摘要**：探讨母乳中LALBA特异性IgA抗体的水平与婴儿肠道菌群发育的关系。结果显示高抗体浓度与双歧杆菌丰度正相关，提示LALBA抗体可能在早期免疫调节中发挥作用。
4. **文献名称**：*Cross-Reactivity of Anti-LALBA Antibodies with Plant-Derived Milk Analogues*
**作者**：Brown, T., et al.
**摘要**：评估商业LALBA抗体与植物基乳制品中类似蛋白的交叉反应性，发现部分抗体对豌豆蛋白存在非特异性结合，提示乳制品过敏诊断中需谨慎选择抗体类型。
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以上示例聚焦于LALBA抗体的检测应用、结构解析、免疫调控及交叉反应性等方向，涵盖基础研究与实际应用场景。实际文献需通过学术数据库检索获取。
Lactalbumin alpha (LALBA), also known as α-lactalbumin, is a small, calcium-binding whey protein predominantly expressed in the mammary gland. It plays a critical role in lactose synthesis as a component of the lactose synthase complex, where it modulates the substrate specificity of galactosyltransferase to produce lactose from glucose and UDP-galactose. Structurally, LALBA belongs to the lysozyme superfamily, though it lacks enzymatic activity. Its expression is hormonally regulated, peaking during lactation.
Antibodies targeting LALBA are widely used in research and diagnostics. They help study lactation biology, mammary gland development, and breast cancer, as altered LALBA levels are linked to tumorigenesis. In the food industry, LALBA-specific antibodies aid in detecting and quantifying bovine α-lactalbumin in dairy products, ensuring quality and allergen labeling compliance. Additionally, LALBA has gained attention for its bioactive peptides, which exhibit antimicrobial and immunomodulatory properties, prompting studies using antibodies to explore their therapeutic potential.
Commercial LALBA antibodies are typically raised in rabbits or mice against purified recombinant or native proteins. Validation methods include Western blotting, immunohistochemistry, and ELISA. Cross-reactivity with LALBA orthologs (e.g., human, bovine, rodent) varies depending on epitope conservation. Challenges include distinguishing LALBA from homologous proteins like lysozyme and ensuring specificity in complex biological matrices. Ongoing research continues to refine antibody-based tools to investigate LALBA’s roles in nutrition, disease, and biotechnology.
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