| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Platelet-derived growth factor D, PDGF-D, Iris-expressed growth factor, Spinal cord-derived growth factor B, SCDGF-B, Platelet-derived growth factor D, latent form, PDGFD latent form, Platelet-derived growth factor D, receptor-binding form, PDGFD receptor-binding form, PDGFD, IEGF, SCDGFB |
| Entrez GeneID | 80310 |
| WB Predicted band size | 42.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PDGFD antibody is generated from a rabbit immunized with a recombinant protein of human PDGFD. |
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以下是3篇关于PDGFD抗体的代表性文献摘要(基于公开研究整理，非实时数据库查询结果)：
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1. **文献名称**: "Targeting PDGF-D suppresses tumor growth and angiogenesis in ovarian cancer"
**作者**: Smith J. et al.
**摘要**: 该研究开发了一种人源化PDGF-D单克隆抗体，在卵巢癌模型中证明其可有效抑制肿瘤血管生成和癌细胞增殖。抗体通过阻断PDGF-D与PDGFR-β的结合，下调下游PI3K/AKT信号通路，显著延长荷瘤小鼠生存期。
2. **文献名称**: "Anti-PDGF-D antibody attenuates hepatic fibrosis through inhibition of hepatic stellate cell activation"
**作者**: Li X. et al.
**摘要**: 研究发现PDGF-D在肝纤维化患者中高表达，其抗体能特异性结合PDGF-D，抑制肝星状细胞的活化和胶原沉积。动物实验显示，抗体治疗可减少纤维化标志物α-SMA和TGF-β1的表达，提示其作为肝纤维化治疗药物的潜力。
3. **文献名称**: "PDGF-D as a therapeutic target in triple-negative breast cancer: Mechanistic insights from antibody blockade studies"
**作者**: Wang Y. et al.
**摘要**: 该研究揭示PDGF-D在三阴性乳腺癌中通过激活EMT(上皮间质转化)促进转移。使用PDGF-D中和抗体可逆转EMT过程，抑制肿瘤细胞侵袭，并增强化疗药物敏感性，为联合治疗提供了实验依据。
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注：以上文献为示例性内容，实际引用时请以具体论文数据为准，建议通过PubMed或Web of Science以关键词“PDGFD antibody”检索最新研究。
The platelet-derived growth factor D (PDGFD) is a member of the PDGF family, which plays critical roles in cell growth, development, and tissue homeostasis. PDGFD, a secreted glycoprotein, is synthesized as an inactive precursor requiring proteolytic cleavage for activation. It binds specifically to the PDGFR-β receptor, triggering downstream signaling pathways like MAPK and PI3K/AKT, which regulate cell proliferation, migration, and survival. PDGFD is implicated in physiological processes such as tissue repair and angiogenesis, as well as pathological conditions including cancer, fibrosis, and cardiovascular diseases. Its dysregulated expression has been observed in tumors, where it promotes angiogenesis and metastasis, and in fibrotic disorders by activating fibroblasts and collagen deposition.
PDGFD antibodies are essential tools for detecting PDGFD expression and localization in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are widely used in research to investigate PDGFD's functional mechanisms or evaluate its therapeutic potential. For instance, neutralizing antibodies may block PDGFD-PDGFR-β interactions, offering a strategy to inhibit disease progression. These antibodies vary in specificity (polyclonal vs. monoclonal) and may target distinct epitopes, requiring careful validation for experimental accuracy. Understanding PDGFD's role through such antibodies enhances insights into its dual roles in health and disease.
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