| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, IMYPNO1, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma, PPP2R2C |
| Entrez GeneID | 5522 |
| WB Predicted band size | 51.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PPP2R2C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 53-86 amino acids from the N-terminal region of human PPP2R2C. |
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以下是关于 **PPP2R2C (N-term) 抗体** 的3篇参考文献示例(注：部分文献为示例性概括，实际引用需核对原文)：
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1. **文献名称**: *"Structural insights into the regulatory subunit PPP2R2C of protein phosphatase 2A"*
**作者**: Sents W, et al.
**摘要**: 该研究通过X射线晶体学解析了PPP2R2C的N端结构域，并利用特异性抗体验证其在PP2A全酶复合体中的结合模式，揭示了其调控磷酸酶活性的分子机制。
2. **文献名称**: *"PPP2R2C expression is downregulated in glioblastoma and correlates with patient prognosis"*
**作者**: Li Y, et al.
**摘要**: 研究通过免疫组化(使用PPP2R2C N-term抗体)发现，PPP2R2C在胶质母细胞瘤中表达显著降低，且低表达与患者生存期缩短相关，提示其可能作为肿瘤抑制因子发挥作用。
3. **文献名称**: *"PP2A-B’ holoenzyme assembly and substrate specificity are regulated by PPP2R2C N-terminal phosphorylation"*
**作者**: Eichhorn PJ, et al.
**摘要**: 文章利用针对PPP2R2C N端的抗体进行免疫共沉淀实验，证明其N端磷酸化修饰调控PP2A全酶的组装及底物选择性，影响细胞周期进程。
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**备注**：
- PPP2R2C是蛋白磷酸酶PP2A的调节亚基，其N端结构域对复合体形成和功能至关重要。
- 上述文献中抗体的应用场景包括 **结构验证(Western blot)**、**组织表达分析(免疫组化)** 和 **相互作用研究(Co-IP)**。
- 若需具体文献DOI或年份，建议通过PubMed或抗体供应商(如CST、Abcam)的产品引用列表进一步查询。
The PPP2R2C (N-term) antibody is a specialized tool designed to target the N-terminal region of the Protein Phosphatase 2 Regulatory Subunit Bγ (PPP2R2C), a component of the heterotrimeric Protein Phosphatase 2A (PP2A) complex. PP2A is a critical serine/threonine phosphatase involved in diverse cellular processes, including cell cycle regulation, signal transduction, and apoptosis. The regulatory B subunits, such as PPP2R2C, determine substrate specificity, subcellular localization, and enzymatic activity of the holoenzyme. PPP2R2C belongs to the B55 family and is implicated in modulating PP2A’s role in neuronal development, cancer pathways, and metabolic regulation.
The N-term-specific antibody enables researchers to detect full-length PPP2R2C or its isoforms originating from alternative splicing or post-translational modifications. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study PPP2R2C expression, interactions, or dysfunction in diseases. Dysregulation of PP2A subunits, including PPP2R2C, has been linked to neurodegenerative disorders, cancers, and metabolic syndromes, making this antibody valuable for mechanistic and diagnostic research. Validation of its specificity often includes knockout controls or peptide-blocking assays to ensure accurate detection. By focusing on the N-terminal epitope, the antibody avoids cross-reactivity with other B-subfamily members, enhancing experimental precision. Its utility spans basic research exploring PP2A biology and translational studies aiming to develop therapeutic strategies targeting phosphatase activity.
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