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| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL-9 |
| Uniprot No | P15248 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 19-144aa |
| 氨基酸序列 | QGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI |
| 预测分子量 | 15.16 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-9重组蛋白的3篇参考文献概览(基于近期研究整理，部分为示例性内容)：
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1. **文献名称**：*Recombinant IL-9 exacerbates allergic inflammation by promoting mast cell and eosinophil activation*
**作者**：Townsend, J.M. et al.
**摘要**：研究利用重组小鼠IL-9蛋白，通过体内实验证明其通过激活肥大细胞和嗜酸性粒细胞，显著加剧过敏性气道炎症，提示IL-9在哮喘病理中的潜在作用机制。
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2. **文献名称**：*IL-9-producing Th9 cells in antitumor immunity: Regulation by recombinant IL-9 and TGF-β signaling*
**作者**：Xiao, X. et al.
**摘要**：探讨重组人IL-9蛋白对Th9细胞分化的调控作用，发现其与TGF-β协同增强T细胞的抗肿瘤活性，为癌症免疫治疗提供新靶点。
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3. **文献名称**：*Recombinant IL-9 enhances intestinal epithelial barrier function via STAT3 signaling*
**作者**：Goswami, R. & Kaplan, M.H.
**摘要**：体外实验表明，重组IL-9蛋白通过激活STAT3通路，促进肠上皮细胞紧密连接蛋白表达，改善炎症性肠病模型中的肠道屏障损伤。
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**备注**：以上为模拟示例，实际文献需通过PubMed、Web of Science或Google Scholar检索关键词“recombinant IL-9”或“Interleukin-9 protein”获取最新研究。推荐使用工具如Zotero管理文献引用。
Interleukin-9 (IL-9), a pleiotropic cytokine belonging to the interleukin-2 (IL-2) family, is primarily produced by activated T-helper 2 (Th2) cells, mast cells, and eosinophils. It plays a multifaceted role in immune regulation, particularly in allergic inflammation, anti-parasitic immunity, and tumor immunity. IL-9 exerts its biological effects by binding to the IL-9 receptor (IL-9R), a heterodimer composed of the IL-9-specific α-chain and the common γ-chain shared with other cytokines. This interaction activates the JAK-STAT, MAPK, and PI3K signaling pathways, influencing the proliferation and differentiation of immune cells such as mast cells, T cells, B cells, and hematopoietic progenitors.
Recombinant IL-9 protein, generated through genetic engineering in systems like *E. coli* or mammalian cells, retains the functional properties of native IL-9. Its production enables precise study of IL-9-mediated pathways in vitro and in vivo. Researchers utilize recombinant IL-9 to investigate its role in disease models, including asthma, autoimmune disorders, and cancer. For example, IL-9 overexpression correlates with mast cell expansion in allergic responses, while its anti-tumor effects in certain malignancies highlight its therapeutic ambiguity.
Pharmaceutically, recombinant IL-9 is explored for immunomodulatory applications, though its dual pro- and anti-inflammatory roles complicate clinical translation. Current studies focus on optimizing delivery mechanisms and understanding context-dependent signaling to harness its therapeutic potential. Despite challenges, recombinant IL-9 remains a critical tool for dissecting immune networks and developing targeted therapies.
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