Rabbit Polyclonal MousePax6 Antibody

The Pax6 protein, encoded by the *PAX6* gene, is a highly conserved transcription factor critical for embryonic development, particularly in eye morphogenesis, central nervous system patterning, and pancreatic differentiation. As a member of the PAX family, it contains paired DNA-binding domains and regulates the expression of downstream genes involved in cell proliferation, differentiation, and tissue specification. Mouse Pax6 antibodies are widely used tools in developmental biology and disease research to detect and localize endogenous Pax6 protein in murine tissues or cells. These antibodies are commonly generated in hosts like rabbits or mice using immunogens derived from specific regions of the mouse Pax6 protein. Validated applications include immunohistochemistry (IHC), immunofluorescence (IF), Western blotting, and flow cytometry. Researchers rely on Pax6 antibodies to study neurogenesis, retinal development, and stem cell maintenance, as Pax6 mutations are linked to congenital disorders such as aniridia. Specificity is confirmed through knockout controls, ensuring minimal cross-reactivity with other PAX family members. Their utility extends to modeling human diseases in mice and exploring regenerative therapies, underscoring their importance in both basic and translational research.