| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Three prime repair exonuclease 2, 3'-5' exonuclease TREX2, TREX2 |
| Entrez GeneID | 11219 |
| WB Predicted band size | 25.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TREX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 264-299 amino acids from the C-terminal region of human TREX2. |
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以下是3-4条关于TREX2抗体的参考文献示例(注：文献信息为模拟生成，实际引用时请核实真实文献):
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1. **文献名称**: *TREX2 maintains genome stability through its exonuclease activity in DNA repair*
**作者**: Perry J.J. et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用TREX2特异性抗体，证明TREX2在哺乳动物细胞中参与复制压力下的DNA损伤修复。抗体验证显示TREX2在多种组织中广泛表达，且其核酸酶活性对维持基因组完整性至关重要。
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2. **文献名称**: *TREX2 deficiency promotes cellular senescence via impaired oxidative damage repair*
**作者**: Chen L. et al.
**摘要**: 通过构建TREX2敲除小鼠模型，结合抗体的免疫组化分析，发现TREX2缺失导致细胞衰老标志物显著增加。研究揭示了TREX2通过修复氧化损伤DNA延缓衰老的分子机制。
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3. **文献名称**: *Antibody-based profiling of TREX2 in human cancers reveals its prognostic significance*
**作者**: Smith R. et al.
**摘要**: 利用商业化TREX2抗体对多种癌症组织进行免疫组织化学染色，发现TREX2高表达与乳腺癌和结直肠癌患者的不良预后相关，提示其作为潜在肿瘤标志物的价值。
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4. **文献名称**: *TREX2 interacts with PCNA and regulates Okazaki fragment processing*
**作者**: Lee S. & Kim H.
**摘要**: 通过共免疫沉淀(Co-IP)和抗体阻断实验，证实TREX2与PCNA直接相互作用，并参与滞后链DNA的加工。研究利用TREX2抗体在体外重组系统中验证了其核酸酶活性对冈崎片段成熟的调控作用。
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**注意**：以上文献信息为示例性质，具体研究请参考真实数据库(如PubMed、Web of Science)中经同行评审的论文。
The TREX2 antibody is a tool used to detect and study the TREX2 protein, a key enzyme involved in DNA repair and maintenance of genomic stability. TREX2 (Three Prime Repair Exonuclease 2) is a 3'→5' exonuclease that processes DNA mismatches and damaged termini, playing roles in error-free DNA replication, recombination, and repair pathways. It interacts with proteins like PCNA and components of the mismatch repair (MMR) system, suggesting its involvement in post-replicative repair. Dysregulation of TREX2 has been linked to diseases such as cancer, autoimmune disorders, and neurodegenerative conditions, as impaired DNA repair mechanisms can lead to mutations or chronic inflammation.
The TREX2 antibody enables researchers to investigate the protein's expression, localization, and function in cellular models or tissues. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have provided insights into TREX2's role in suppressing genomic instability, modulating immune responses, and influencing cellular responses to replication stress or DNA damage. Its applications extend to exploring therapeutic targets for diseases associated with defective DNA repair. Commercial TREX2 antibodies are typically validated for specificity and sensitivity, ensuring reliable detection across experimental setups.
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