Rabbit Polyclonal (Mouse)Cldn6 Antibody

CLDN6. a member of the claudin family, is a transmembrane protein critical for forming tight junctions that regulate paracellular permeability and maintain cell polarity. Primarily expressed during embryonic development, CLDN6 shows restricted expression in adult tissues but is frequently re-expressed in various cancers, including germ cell tumors, gastric cancer, and ovarian cancer. This oncofetal protein has gained attention as a potential therapeutic target and diagnostic biomarker due to its tumor-specific expression. Mouse CLDN6 (mCLDN6) antibodies are tools developed to detect and study the function of CLDN6 in murine models. These antibodies enable researchers to investigate CLDN6's role in tumorigenesis, cell adhesion, and barrier function, as well as its interaction with signaling pathways like Wnt/β-catenin. They are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to validate CLDN6 expression in genetically engineered mouse models or xenograft studies. Additionally, mCLDN6 antibodies support preclinical testing of CLDN6-targeted therapies, including antibody-drug conjugates (ADCs) or immunotherapies. Their specificity for murine CLDN6 ensures accurate cross-species comparison, aiding translational research while addressing challenges like antibody cross-reactivity with other claudin family members (e.g., CLDN3. CLDN4).