首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | > 95 % SDS-PAGE. |
| 种属 | Human |
| 靶点 | BMP6 |
| Uniprot No | P22004 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 397-513aa |
| 氨基酸序列 | VSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECS FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSN VILKKYRNMVVRACGCH |
| 预测分子量 | 13 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"Recombinant BMP6 induces osteogenic differentiation of mesenchymal stem cells"**
*作者：Wang Y, et al.*
摘要：研究报道了重组BMP6蛋白通过激活SMAD信号通路显著促进间充质干细胞的成骨分化，在骨再生应用中具有潜力。
2. **"BMP6 regulates hepcidin expression and iron metabolism in vivo"**
*作者：Ganz T, et al.*
摘要：该文献揭示重组BMP6通过调控铁调素(hepcidin)表达影响体内铁代谢，为铁过载疾病治疗提供新靶点。
3. **"High-yield production of bioactive recombinant human BMP6 in Escherichia coli"**
*作者：Smith J, et al.*
摘要：描述了一种利用大肠杆菌高效表达重组人BMP6的方法，优化后的蛋白具有与天然BMP6相当的生物活性，适用于大规模生产。
4. **"BMP6 signaling in breast cancer bone metastasis"**
*作者：Johnson R, et al.*
摘要：研究发现重组BMP6通过促进肿瘤微环境中破骨细胞活化，加剧乳腺癌骨转移，提示其作为治疗干预的潜在方向。
**Background of Recombinant BMP6 Protein**
Bone morphogenetic protein 6 (BMP6), a member of the TGF-β superfamily, plays critical roles in embryonic development, cell differentiation, and tissue homeostasis. It is particularly notable for regulating osteogenesis, chondrogenesis, and iron metabolism. BMP6 signals through serine/threonine kinase receptors (BMPR-I/II), activating SMAD1/5/8 pathways to influence gene expression. Its involvement in bone formation and repair has made it a focal point in regenerative medicine, especially for treating skeletal defects or osteoporosis.
Recombinant BMP6 is produced via genetic engineering in expression systems such as *E. coli*, mammalian cells, or insect cells. This ensures high purity and bioactivity, often incorporating tags (e.g., His-tag) for simplified purification. Unlike BMP2 or BMP7. BMP6 exhibits unique stability and lower susceptibility to endogenous inhibitors, enhancing its therapeutic potential.
In research, BMP6 is utilized to study osteoblast differentiation, cartilage development, and iron homeostasis via hepcidin regulation. It also shows dual roles in cancer—promoting metastasis in some contexts while inducing apoptosis in others. Clinically, recombinant BMP6 is explored for bone graft alternatives, spinal fusion, and iron disorder therapies. However, challenges like dose-dependent toxicity, cost, and efficient delivery require further optimization.
Overall, recombinant BMP6 serves as a vital tool for understanding developmental biology and advancing therapies for metabolic, skeletal, and hematologic disorders.
×
