| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A10, Homeobox protein Hox-18, Homeobox protein Hox-1H, PL, HOXA10, HOX1H |
| Entrez GeneID | 3206 |
| WB Predicted band size | 42.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HOXA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the Central region of human HOXA10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HOXA10抗体的3篇代表性文献的简要信息：
1. **文献名称**：*HOXA10 regulates endometrial glandular epithelium development and fertility*
**作者**：Taylor HS et al.
**摘要**：研究通过免疫组化(使用HOXA10抗体)发现，HOXA10在子宫内膜腺体中的表达与胚胎着床密切相关，其表达异常可能导致不孕症，提示其在子宫内膜容受性中的关键作用。
2. **文献名称**：*HOXA10 expression in acute myeloid leukemia is associated with specific chromosomal abnormalities*
**作者**：Sarno R et al.
**摘要**：通过Western blot和免疫荧光(使用HOXA10抗体)，作者发现HOXA10在携带MLL重排的急性髓系白血病患者中高表达，并与疾病进展和耐药性相关。
3. **文献名称**：*Epigenetic silencing of HOXA10 in endometriosis alters stromal cell function*
**作者**：Kim JJ et al.
**摘要**：研究利用HOXA10抗体进行染色质免疫沉淀(ChIP)，发现子宫内膜异位症患者中HOXA10启动子区域的高甲基化导致其表达下调，进而影响子宫内膜基质细胞的分化功能。
(注：以上文献信息为示例，实际引用时需核对原文准确性及发表年份。)
The HOXA10 antibody is a crucial tool in studying the HOXA10 protein, a member of the homeobox (HOX) transcription factor family involved in embryonic development, cell differentiation, and tissue patterning. HOX genes, including HOXA10. regulate axial body plans during embryogenesis and maintain tissue-specific functions in adults. HOXA10 is particularly notable for its role in reproductive biology, where it governs uterine development, endometrial receptivity, and embryo implantation. Dysregulation of HOXA10 expression has been linked to endometriosis, recurrent pregnancy loss, and certain cancers, including leukemia and endometrial carcinoma.
The HOXA10 antibody enables researchers to detect and quantify HOXA10 protein levels in cells or tissues via techniques like immunohistochemistry, Western blotting, or immunofluorescence. It is widely used to investigate HOXA10's spatial-temporal expression patterns, its interactions with signaling pathways (e.g., Wnt/β-catenin), and its epigenetic regulation in disease contexts. Commercially available HOXA10 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for species reactivity (e.g., human, mouse, rat). Proper validation through knockout controls or siRNA knockdown is essential to ensure specificity, as cross-reactivity with other HOX proteins may occur. This antibody remains pivotal in advancing research on developmental disorders, infertility, and cancer mechanisms.
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