| WB | 1/1000 | Mouse, Rat |
| IF | 咨询技术 | Mouse, Rat |
| IHC | 咨询技术 | Mouse, Rat |
| ICC | 技术咨询 | Mouse, Rat |
| FCM | 咨询技术 | Mouse, Rat |
| Elisa | 咨询技术 | Mouse, Rat |
| Aliases | CCAAT/enhancer-binding protein beta, C/EBP beta, C/EBP-related protein 2, Interleukin-6-dependent-binding protein, IL-6DBP, Liver-enriched inhibitory protein, LIP, Liver-enriched transcriptional activator, LAP, Silencer factor B, SF-B, Cebpb, Crp2, Sfb |
| Entrez GeneID | 24253 |
| WB Predicted band size | 31.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse, Rat |
| Immunogen | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-131 amino acids from Rat. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Rat-Cebpb-S105抗体的3篇参考文献示例(内容基于模拟文献，供参考)：
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1. **文献名称**：*Phosphorylation of C/EBPβ at Ser105 regulates hepatic regeneration in rat models*
**作者**：Li et al.
**摘要**：本研究揭示了大鼠肝脏再生过程中C/EBPβ的磷酸化调控机制，通过使用Rat-Cebpb-S105特异性抗体，证实S105位点的磷酸化在肝细胞增殖中起关键作用，并影响下游靶基因表达。
2. **文献名称**：*Role of C/EBPβ-S105 phosphorylation in adipocyte differentiation*
**作者**：Park & Spiegelman
**摘要**：文章探讨了大鼠前脂肪细胞分化中C/EBPβ的翻译后修饰，利用Rat-Cebpb-S105抗体发现S105磷酸化通过调控PPARγ通路促进脂肪生成，为代谢疾病研究提供新靶点。
3. **文献名称**：*Inflammatory signaling modulates C/EBPβ phosphorylation in macrophages*
**作者**：Smith et al.
**摘要**：研究通过Western blot和免疫荧光技术(使用Rat-Cebpb-S105抗体)，证明LPS激活的大鼠巨噬细胞中S105磷酸化增强，驱动炎症因子释放，提示其在固有免疫中的调控作用。
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注：以上文献为模拟示例，实际引用需通过PubMed、Google Scholar等平台检索真实文献。若需具体文献，建议结合抗体供应商(如CST、Abcam)提供的产品引用文献。
The Rat-Cebpb-S105 antibody is a phospho-specific antibody designed to detect the phosphorylated form of CCAAT/enhancer-binding protein beta (C/EBPβ) at serine residue 105 (S105) in rat-derived samples. C/EBPβ is a transcription factor critical for regulating genes involved in immune responses, cell differentiation, metabolism, and oncogenesis. Phosphorylation at S105. a key post-translational modification, modulates C/EBPβ's transcriptional activity, DNA-binding affinity, and interactions with co-regulators. This modification is often induced by signaling pathways such as MAPK/ERK, which are activated during inflammation, stress, or growth signals.
The Rat-Cebpb-S105 antibody is widely used in research to investigate the role of C/EBPβ activation in physiological and pathological contexts. Applications include Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation status in tissue samples, cultured cells, or disease models. Its specificity for the phosphorylated epitope makes it valuable for studying dynamic regulatory mechanisms, such as macrophage polarization, adipocyte differentiation, or tumor progression. Validation typically involves knockout controls or phosphatase treatment to confirm signal dependence on S105 phosphorylation. Researchers employ this antibody to explore molecular pathways linking C/EBPβ activity to conditions like obesity, diabetes, and cancer, providing insights into therapeutic targets. Commercial sources often provide detailed species reactivity and cross-reactivity data to ensure experimental accuracy.
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