Rabbit Polyclonal MouseCdk1 Antibody

The mouse Cdk1 (Cyclin-dependent kinase 1) antibody is a critical tool for studying cell cycle regulation and proliferation mechanisms. Cdk1. also known as Cdc2. is a serine/threonine kinase that plays a central role in controlling the G2/M phase transition during the cell cycle. It forms complexes with cyclin B to drive mitotic entry by phosphorylating substrates involved in nuclear envelope breakdown, chromatin condensation, and spindle assembly. Dysregulation of Cdk1 is associated with cancer, developmental disorders, and other pathologies linked to uncontrolled cell division. The mouse-specific Cdk1 antibody is commonly generated in hosts like rabbits or mice, targeting unique epitopes within the murine Cdk1 protein. It is widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and interaction partners in mouse cell lines or tissues. Validated antibodies exhibit high specificity, distinguishing Cdk1 from other CDK family members (e.g., Cdk2 or Cdk4). Researchers employ this antibody in studies exploring cell cycle checkpoints, cancer biology, stem cell differentiation, and drug discovery targeting mitotic regulators. Proper controls, such as knockout cell lines or siRNA-mediated knockdown, are essential to confirm antibody specificity in experimental setups.