| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF |
| Entrez GeneID | 7050 |
| WB Predicted band size | 43.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TGIF1 (N-term)抗体的3篇参考文献的简要概括(注：文献为模拟示例，实际引用时请核实原文)：
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1. **文献名称**: *TGIF1 regulates embryonic stem cell pluripotency through interaction with OCT4*
**作者**: Smith J, et al.
**摘要**: 本研究利用TGIF1 (N-term)特异性抗体，通过免疫沉淀和Western blot分析，揭示了TGIF1与OCT4转录因子的相互作用，证明其在维持胚胎干细胞多能性中的关键作用。
2. **文献名称**: *TGIF1 modulates TGF-β signaling in hepatocellular carcinoma progression*
**作者**: Lee H, et al.
**摘要**: 通过TGIF1 (N-term)抗体的免疫组化染色，作者发现TGIF1在肝癌组织中高表达，并证实其通过抑制TGF-β通路促进肿瘤侵袭转移的分子机制。
3. **文献名称**: *Characterization of TGIF1 isoforms in neuronal development*
**作者**: Garcia R, et al.
**摘要**: 该研究使用TGIF1 (N-term)抗体进行亚细胞定位分析，发现TGIF1的不同剪接体在神经元分化过程中具有差异表达，并调控突触形成相关基因。
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如需实际文献，建议通过PubMed或Google Scholar搜索关键词“TGIF1 antibody N-terminal”或结合具体研究领域筛选。部分抗体生产商(如Abcam、Cell Signaling)的技术文档也可能提供引用范例。
The TGIF1 (N-term) antibody is a tool designed to detect the N-terminal region of TG-interacting factor 1 (TGIF1), a transcriptional repressor involved in regulating developmental pathways and cellular processes. TGIF1. a member of the TALE (Three-Amino acid Loop Extension) homeodomain protein family, binds to DNA via its homeodomain and interacts with transcription factors like SMAD2/3 to modulate signaling pathways, including TGF-β and retinoic acid (RA) signaling. By recruiting co-repressors such as HDACs and Polycomb group proteins, TGIF1 represses target gene expression, influencing cell differentiation, proliferation, and apoptosis.
The N-terminal region of TGIF1 contains critical functional domains responsible for protein-protein interactions, including binding to nuclear receptors and transcriptional co-repressors. Antibodies targeting this region are valuable for studying TGIF1's role in transcriptional regulation, its subcellular localization, and its interplay with signaling cascades. They are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TGIF1 expression and function in various contexts, such as embryonic development and disease.
TGIF1 dysregulation has been linked to cancers (e.g., breast, gastric) and developmental disorders like holoprosencephaly. The TGIF1 (N-term) antibody aids in exploring these associations, offering insights into disease mechanisms and potential therapeutic targets. Its specificity for the N-terminus ensures recognition of full-length TGIF1. distinguishing it from splice variants or degradation products.
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