| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cone-rod homeobox protein, CRX, CORD2 |
| Entrez GeneID | 1406 |
| WB Predicted band size | 32.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CRX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-297 amino acids from the C-terminal region of human CRX. |
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以下是关于CRX抗体的3篇参考文献及其摘要：
1. **文献名称**: *Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation*
**作者**: Furukawa, T., Morrow, E. M., & Cepko, C. L.
**摘要**: 该研究首次克隆了CRX基因，并开发了特异性抗体用于检测其在视网膜中的表达。研究发现CRX在光感受器细胞(视杆和视锥细胞)中特异性表达，并通过调控光感受器特异性基因(如视紫红质)的转录，参与细胞分化。抗体实验证实CRX在小鼠视网膜发育中的关键作用。
2. **文献名称**: *Mutations in the cone-rod homeobox gene associated with cone-rod dystrophy and Leber congenital amaurosis*
**作者**: Chen, S., Wang, Q. L., Xu, S., et al.
**摘要**: 本研究通过CRX抗体对患者视网膜样本进行免疫组化分析，发现CRX基因突变导致蛋白功能异常，进而引发遗传性视网膜疾病(如锥杆细胞营养不良和Leber先天性黑蒙)。抗体检测显示突变患者的CRX蛋白表达显著减少或定位异常。
3. **文献名称**: *CRX directs transcriptional and chromatin reprogramming during photoreceptor differentiation*
**作者**: Hennig, A. K., Peng, G. H., & Chen, S.
**摘要**: 该研究利用CRX抗体进行染色质免疫沉淀(ChIP-seq)和共聚焦成像，揭示CRX通过结合靶基因启动子并招募染色质重塑复合物，调控光感受器分化过程中的基因表达动态。抗体实验表明CRX在表观遗传修饰中起核心作用。
4. **文献名称**: *Role of the retinal cone-rod homeobox (CRX) gene in photoreceptor development and maintenance*
**作者**: Swain, P. K., Hicks, D., Mears, A. J., et al.
**摘要**: 通过CRX抗体标记及基因敲除小鼠模型，研究发现CRX对光感受器细胞的发育和存活至关重要。抗体染色显示，CRX缺失导致视网膜结构紊乱及光感受器特异性基因表达丧失，证实其作为转录调控因子的核心地位。
以上文献均涉及CRX抗体的应用，涵盖基因功能、疾病机制及分子调控研究，为视网膜生物学领域的重要参考。
CRX (Cone-Rod Homeobox) antibody is a crucial tool in studying retinal development and photoreceptor function. CRX, encoded by the *CRX* gene, is a transcription factor essential for the differentiation and maintenance of cone and rod photoreceptor cells in the retina. It regulates the expression of photoreceptor-specific genes, including those involved in light signal transduction (e.g., opsins) and synaptic transmission. Mutations in *CRX* are linked to inherited retinal diseases such as Leber congenital amaurosis (LCA), cone-rod dystrophy, and retinitis pigmentosa, underscoring its role in retinal health.
CRX antibodies are widely used in research to detect CRX protein expression via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These applications help map CRX localization in retinal tissues, assess its expression levels in disease models, and investigate molecular mechanisms underlying photoreceptor degeneration. Additionally, CRX antibodies aid in characterizing induced pluripotent stem cell (iPSC)-derived retinal organoids, advancing studies on retinal regeneration and gene therapy. Their specificity and reliability make them indispensable for both basic research and preclinical studies targeting CRX-associated retinal pathologies.
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