Rabbit Polyclonal AGAP8 Antibody

The AGAP8 antibody targets the ARFGAP with GTPase domain, ANK repeat, and PH domain-containing protein 8 (AGAP8), a member of the ArfGAP protein family involved in regulating ADP-ribosylation factor (Arf) GTPases. AGAP8 modulates vesicle trafficking, cytoskeletal reorganization, and membrane remodeling by promoting GTP hydrolysis of Arfs, switching them from active (GTP-bound) to inactive (GDP-bound) states. It contains conserved domains, including a GTPase-activating protein (GAP) domain, which facilitates this catalytic activity, as well as pleckstrin homology (PH) and ankyrin (ANK) repeats, suggesting roles in lipid binding and protein-protein interactions. AGAP8 is implicated in cellular processes like endocytosis, receptor signaling, and intracellular transport. Research on AGAP8 antibodies focuses on detecting protein expression, localization, and functional studies in cancer, neurological disorders, and immune regulation. Dysregulation of AGAP8 has been linked to tumor progression, synaptic plasticity defects, and immune cell dysfunction. Antibodies against AGAP8 (often raised in rabbits or mice) are validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into its molecular mechanisms and therapeutic potential. Specificity, clonality, and epitope information vary by commercial source.