首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL-20 |
| Uniprot No | Q9NYY1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 25-176aa |
| 氨基酸序列 | LKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDT KPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLR LCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEE TE |
| 预测分子量 | 17 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-20重组蛋白的3篇文献参考(示例为虚构，实际需根据真实文献调整)：
1. **文献名称**：*IL-20 promotes angiogenesis in vitro and in vivo via JNK signaling*
**作者**：Smith A, et al.
**摘要**：研究利用重组IL-20蛋白处理内皮细胞，发现其通过激活JNK通路显著促进血管生成，并在小鼠缺血模型中验证了促血管新生的作用。
2. **文献名称**：*Recombinant IL-20 exacerbates psoriasis-like inflammation in a murine model*
**作者**：Chen L, et al.
**摘要**：通过皮下注射重组IL-20蛋白诱导小鼠皮肤炎症，证实IL-20通过上调促炎因子(如TNF-α和IL-17)加重银屑病样病变。
3. **文献名称**：*IL-20 regulates osteoblast differentiation and bone metabolism through STAT3*
**作者**：Wang Y, et al.
**摘要**：体外实验表明，重组IL-20蛋白抑制成骨细胞分化，并依赖STAT3信号通路，提示其在骨质疏松等骨代谢疾病中的潜在病理作用。
(注：以上为示例模板，实际引用需查找具体文献并核对作者及摘要内容。)
Interleukin-20 (IL-20) is a member of the IL-10 cytokine family, which includes IL-10. IL-19. IL-22. and others. Discovered in the early 2000s, IL-20 plays a critical role in regulating inflammatory responses, particularly in epithelial tissues and skin. It signals through two heterodimeric receptor complexes: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. These receptors are expressed on keratinocytes, endothelial cells, and immune cells, linking IL-20 to skin homeostasis, wound healing, and pathological conditions like psoriasis and rheumatoid arthritis.
Recombinant IL-20 protein is produced using biotechnological systems, such as Escherichia coli or mammalian cell cultures, to ensure proper folding and post-translational modifications. The protein typically retains its functional activity, enabling researchers to study its biological effects in vitro and in vivo. Studies have shown that IL-20 promotes angiogenesis, osteoclastogenesis, and the production of pro-inflammatory cytokines, contributing to chronic inflammatory diseases and bone resorption disorders. Its overexpression in psoriasis lesions and atherosclerotic plaques highlights its therapeutic relevance.
The development of recombinant IL-20 has facilitated drug discovery efforts, including neutralizing antibodies or inhibitors targeting IL-20 or its receptors. Conversely, engineered IL-20 variants are explored for regenerative applications, such as enhancing tissue repair. However, its dual role in inflammation and tissue remodeling requires careful modulation to avoid adverse effects. Current research also investigates IL-20's involvement in cancer progression, where it may influence tumor microenvironment interactions. Overall, recombinant IL-20 remains a vital tool for unraveling its complex biology and advancing targeted therapies.
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