| WB | 1/1000 | Rat |
| IF | 咨询技术 | Rat |
| IHC | 咨询技术 | Rat |
| ICC | 技术咨询 | Rat |
| FCM | 咨询技术 | Rat |
| Elisa | 咨询技术 | Rat |
| Aliases | Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask |
| Entrez GeneID | 29647 |
| WB Predicted band size | 103.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CASK蛋白及其抗体的研究文献示例(内容为模拟概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *CASK interacts with neurexin signaling to regulate synaptic protein networks*
**作者**: Hata Y. et al.
**摘要**: 研究CASK蛋白在突触形成中的作用，通过免疫共沉淀和Western blot技术验证其与神经连接蛋白(neurexin)的相互作用，使用兔源多克隆抗体(R CASK)定位CASK在神经元突触中的分布，揭示其对突触蛋白网络的调控机制。
2. **文献名称**: *CASK mutations lead to X-linked intellectual disability and altered dendritic spine morphology*
**作者**: Hsueh Y.P. et al.
**摘要**: 分析CASK基因突变与X连锁智力障碍的关联，利用CASK特异性抗体在小鼠模型中进行免疫组织化学分析，发现突变导致树突棘形态异常，提示CASK在神经发育中的关键作用。
3. **文献名称**: *Antibody validation for CASK in human and mouse brain tissues*
**作者**: Mukherjee K. et al.
**摘要**: 系统性验证多种CASK抗体的特异性(包括兔源单抗R CASK-2)，通过敲除细胞模型和脑组织切片证明抗体在免疫荧光和Western blot中的可靠性，为神经疾病研究提供实验依据。
4. **文献名称**: *Proteomic profiling of CASK-associated complexes in synaptic membranes*
**作者**: Najm J. et al.
**摘要**: 采用CASK抗体富集突触膜蛋白复合物，结合质谱技术鉴定其相互作用蛋白，揭示CASK在维持突触可塑性和信号转导中的多重功能。
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**提示**：实际文献需通过PubMed/Google Scholar检索关键词如“CASK antibody”、“CASK protein function”或结合具体研究领域(如神经科学、分子生物学)。部分经典研究可能发表于*Nature Neuroscience*、*Journal of Neuroscience*等期刊。
**Background of R CASK Antibody**
The CASK (Calcium/Calmodulin-Dependent Serine Protein Kinase) protein is a membrane-associated guanylate kinase (MAGUK) family member, crucial for synaptic organization, neuronal development, and signaling. It interacts with multiple partners, including neurexins, syndecans, and transcription factors, bridging extracellular signals to intracellular pathways. CASK mutations are linked to neurodevelopmental disorders such as X-linked intellectual disability, microcephaly, and autism spectrum disorders.
The R CASK antibody, often generated in rabbits or other model organisms, is a recombinant or monoclonal tool designed to target specific epitopes of the CASK protein. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CASK expression, localization, and interactions in tissues or cultured cells. Its high specificity enables researchers to investigate CASK's role in synaptic plasticity, neural circuit formation, and disease mechanisms.
Recent studies emphasize CASK's involvement in regulating gene expression via its nuclear translocation, adding complexity to its functions. The R CASK antibody aids in exploring these diverse roles, offering insights into therapeutic targets for CASK-related neurological conditions. Validation through knockout controls or peptide blocking ensures reliability, making it a cornerstone in neuroscience and molecular biology research.
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