| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin-conjugating enzyme E2 R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2, UBE2R2, CDC34B, UBC3B |
| Entrez GeneID | 54926 |
| WB Predicted band size | 27.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This UBE2R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-169 amino acids from the Central region of human UBE2R2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于UBE2R2抗体的3篇代表性文献(均为模拟示例，实际文献需根据具体数据库检索)：
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1. **文献名称**：*UBE2R2 regulates cell cycle progression via APC/C-dependent proteolysis in cancer cells*
**作者**：Chen L, et al.
**摘要**：研究揭示了UBE2R2作为E2泛素结合酶与APC/C复合体相互作用，通过降解细胞周期蛋白调控肿瘤细胞有丝分裂。研究中采用UBE2R2抗体进行免疫共沉淀和Western blot分析，证实其在结直肠癌中异常高表达。
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2. **文献名称**：*Development and validation of a specific monoclonal antibody for UBE2R2 in neurodegenerative models*
**作者**：Wang Y, et al.
**摘要**：本文报道了一种新型UBE2R2单克隆抗体的开发，通过免疫组化验证其在阿尔茨海默病小鼠脑组织中的定位，发现UBE2R2与tau蛋白异常泛素化相关，提示其可能参与神经退行性病变机制。
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3. **文献名称**：*UBE2R2-AS1 lncRNA interacts with UBE2R2 protein to promote hepatocellular carcinoma metastasis*
**作者**：Zhang H, et al.
**摘要**：通过RNA pull-down和ChIP实验结合UBE2R2抗体，研究发现UBE2R2-AS1长链非编码RNA与UBE2R2蛋白直接结合，增强HCC细胞的侵袭能力，表明UBE2R2抗体在探索RNA-蛋白互作网络中的关键作用。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“UBE2R2 antibody”、“UBE2R2 function”或结合研究领域(如癌症、泛素化)。
The UBE2R2 antibody is a crucial tool in studying the ubiquitin-proteasome system (UPS), a pathway essential for protein degradation and cellular homeostasis. UBE2R2 (Ubiquitin-Conjugating Enzyme E2 R2), also known as CDC34B, belongs to the E2 ubiquitin-conjugating enzyme family, which works with E3 ligases to transfer ubiquitin to substrate proteins, marking them for proteasomal degradation. UBE2R2 shares homology with UBE2R1 (CDC34A) and is implicated in cell cycle regulation, DNA repair, and signal transduction. Dysregulation of UBE2R2 is linked to cancers, neurodegenerative diseases, and immune disorders.
UBE2R2 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. These antibodies enable detection and quantification of UBE2R2 expression via techniques such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Specificity is validated through knockout controls or siRNA-mediated knockdown. Researchers use these antibodies to explore UBE2R2’s role in ubiquitination cascades, its interaction with E3 ligases (e.g., SCF complexes), and its impact on pathological conditions. Commercial UBE2R2 antibodies often include validation data to ensure reliability in diverse experimental models, aiding mechanistic studies of UPS-related diseases and therapeutic target discovery.
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