| WB | DB: 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA, OSIL |
| Entrez GeneID | 8878 |
| WB Predicted band size | 47.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SQSTM1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S207 of human SQSTM1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Phospho-SQSTM1(S207)抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需核实)：
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1. **文献名称**：*SQSTM1 phosphorylation at Ser207 regulates autophagic degradation in neurodegenerative models*
**作者**：Li et al. (2020)
**摘要**：研究揭示了SQSTM1/p62在丝氨酸207位点(S207)磷酸化对其介导的自噬功能的影响，通过Phospho-SQSTM1(S207)抗体检测发现，该修饰增强了错误折叠蛋白的聚集清除能力，为阿尔茨海默病治疗提供新靶点。
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2. **文献名称**：*Phosphorylation-dependent regulation of SQSTM1 in cancer metastasis*
**作者**：Chen & Wang (2018)
**摘要**：文章利用Phospho-SQSTM1(S207)抗体进行免疫印迹分析，发现S207磷酸化通过激活NF-κB通路促进肿瘤细胞侵袭，提示其在癌症转移中的关键作用。
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3. **文献名称**：*The role of p62/SQSTM1 phosphorylation in selective autophagy under oxidative stress*
**作者**：Yamamoto et al. (2021)
**摘要**：通过免疫荧光和共聚焦显微镜技术，研究发现S207磷酸化调控p62与LC3的相互作用，Phospho-SQSTM1(S207)抗体的应用证实该修饰是氧化应激下线粒体自噬的重要调控节点。
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(注：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索真实文献。)
**Phospho-SQSTM1(S207) Antibody Background**
The Phospho-SQSTM1(S207) antibody specifically detects SQSTM1 (sequestosome 1. also known as p62) when phosphorylated at serine 207. SQSTM1/p62 is a multifunctional scaffold protein involved in selective autophagy, cellular stress responses, and signal transduction. It acts as an autophagy receptor, targeting ubiquitinated substrates for degradation via the autophagy-lysosome pathway. Phosphorylation at Ser207 regulates SQSTM1/p62 activity, influencing its interactions with binding partners like Keap1 in the Keap1-Nrf2 antioxidant response pathway or modulating autophagic flux.
This phosphorylation event has been implicated in cellular adaptation to oxidative stress, nutrient deprivation, and proteotoxic conditions. Dysregulation of SQSTM1/p62 is linked to neurodegenerative diseases, cancer, and metabolic disorders, making its phosphorylation status a focus in studying disease mechanisms. The Phospho-SQSTM1(S207) antibody is a critical tool for investigating post-translational modifications of SQSTM1/p62. enabling researchers to explore its role in autophagy, protein aggregation diseases (e.g., Alzheimer’s, ALS), and cancer progression. It is widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to assess phosphorylation dynamics in response to cellular stressors or therapeutic interventions.
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