| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Multiple C2 and transmembrane domain-containing protein 2, MCTP2 |
| Entrez GeneID | 55784 |
| WB Predicted band size | 99.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MCTP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the N-terminal region of human MCTP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MCTP2 (N-term)抗体的参考文献示例(内容为模拟，建议通过学术数据库验证具体文献)：
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1. **"MCTP2 N-terminal Antibody Characterization in Neural Development"**
*Authors: Smith A, Lee B, Patel R*
**摘要**：本研究验证了一种针对MCTP2蛋白N端的多克隆抗体，通过免疫印迹和免疫荧光技术检测其在哺乳动物神经元中的表达。结果表明，该抗体特异性识别MCTP2的N端结构域，并揭示其在突触形成中的潜在作用。
2. **"Structural Insights into MCTP2 Function via Domain-Specific Antibodies"**
*Authors: Zhang Y, Kimura T, Wang H*
**摘要**：通过开发针对MCTP2不同结构域的抗体(包括N端)，探讨了其与钙离子结合的C2结构域互作机制。N端抗体在共免疫沉淀实验中证实参与调控细胞内囊泡运输。
3. **"MCTP2 as a Biomarker in Cardiovascular Disease: Antibody-Based Detection"**
*Authors: Gupta S, et al.*
**摘要**：利用MCTP2 N端抗体分析其在心肌细胞中的表达变化，发现其在心脏肥大模型中的上调，提示其可能作为疾病标志物。抗体特异性经siRNA敲除实验验证。
4. **"Development of a High-Specificity MCTP2 N-term Monoclonal Antibody"**
*Authors: Tanaka K, et al.*
**摘要**：报道了一种新型单克隆抗体的制备，靶向MCTP2 N端抗原表位。通过ELISA和质谱分析证实其高亲和力与特异性，适用于组织切片中蛋白定位研究。
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**注**：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science等平台检索真实文献，并核对抗体货号(如Santa Cruz Biotechnology等厂商可能提供相关产品文献)。
The MCTP2 (Multiple C2 and Transmembrane Domain Protein 2) antibody targets the N-terminal region of the MCTP2 protein, a member of the MCTP family characterized by multiple C2 domains and transmembrane regions. MCTP2 is implicated in intracellular signaling, membrane trafficking, and calcium-dependent processes, particularly in neuronal and cardiovascular systems. Its structural domains suggest roles in bridging membranes or facilitating protein interactions, potentially influencing synaptic plasticity, neural development, or cardiac function.
The N-terminal-specific antibody is commonly used to study MCTP2 expression, localization, and molecular interactions in tissues or cultured cells via techniques like Western blot, immunohistochemistry, or immunoprecipitation. Research highlights its involvement in neurodevelopmental disorders and cardiac arrhythmias, with animal models linking MCTP2 dysregulation to abnormal neural connectivity or heart rhythm defects. The antibody’s specificity is often validated using knockout controls or epitope-mapping assays.
As MCTP2’s full functional scope remains under investigation, this antibody serves as a critical tool for unraveling its physiological and pathological roles, particularly in contexts like neural network formation or ion channel regulation. Species reactivity typically includes human, mouse, and rat homologs.
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