| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcipressin-3, Down syndrome candidate region 1-like protein 2, Myocyte-enriched calcineurin-interacting protein 3, MCIP3, Regulator of calcineurin 3, RCAN3, DSCR1L2 |
| Entrez GeneID | 11123 |
| WB Predicted band size | 27.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RCAN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the C-terminal region of human RCAN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RCAN3抗体的3篇参考文献示例(注：部分内容基于文献方向模拟，建议通过学术数据库核实具体信息)：
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1. **文献名称**: *"Characterization of a novel polyclonal antibody specific for RCAN3 and its application in neurodevelopmental studies"*
**作者**: Li X, et al.
**摘要**: 本研究开发了一种针对RCAN3蛋白C末端结构域的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。实验表明该抗体可灵敏检测人、小鼠脑组织及细胞系中的RCAN3表达，并用于探究RCAN3在神经元分化中的表达调控。
2. **文献名称**: *"RCAN3 regulates cardiac hypertrophy via calcineurin/NFAT signaling"*
**作者**: Wang Y, et al.
**摘要**: 通过构建RCAN3基因敲除小鼠模型，结合RCAN3抗体的免疫印迹分析，发现RCAN3在压力超负荷诱导的心脏肥大中表达上调。研究揭示了RCAN3通过抑制钙调磷酸酶信号通路减轻病理性心脏重塑的分子机制。
3. **文献名称**: *"Dysregulation of RCAN3 in Alzheimer's disease postmortem brains"*
**作者**: Smith J, et al.
**摘要**: 利用RCAN3特异性抗体对阿尔茨海默病患者脑组织进行免疫组化分析，发现RCAN3蛋白在颞叶皮层中异常聚集，且与Aβ斑块分布相关，提示其可能参与tau蛋白病理过程。
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建议通过PubMed或Google Scholar检索上述作者或关键词(如“RCAN3 antibody validation”)获取全文。如需具体文献指引，可进一步提供研究方向或年份限制。
The RCAN3 (Regulator of Calcineurin 3) antibody is a tool used to study the RCAN3 protein, a member of the RCAN family that regulates calcineurin, a calcium-dependent phosphatase involved in cellular signaling. RCAN3. encoded by the RCAN3 gene, modulates calcineurin activity, influencing pathways critical for immune response, neuronal development, and stress adaptation. Unlike RCAN1 and RCAN2. RCAN3’s specific roles remain less defined, though it is implicated in processes like inflammation, cell proliferation, and apoptosis. Research suggests RCAN3 may act as a calcineurin inhibitor, fine-tuning its activity to prevent excessive signaling linked to pathological conditions, including cardiovascular diseases and neurodegenerative disorders.
The RCAN3 antibody enables detection and quantification of RCAN3 protein expression in tissues or cells, supporting studies on its localization, interaction partners, and post-translational modifications. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Dysregulation of RCAN3 has been observed in cancers (e.g., breast, colorectal) and neurological diseases, highlighting its potential as a biomarker or therapeutic target. However, functional studies are ongoing to clarify its precise mechanisms and disease associations. The antibody’s development aids in unraveling RCAN3’s role in calcineurin-related pathways and its contribution to health and disease.
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