| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integral membrane protein GPR137, Transmembrane 7 superfamily member 1-like 1 protein, GPR137, C11orf4, GPR137A, TM7SF1L1 |
| Entrez GeneID | 56834 |
| WB Predicted band size | 46.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GPR137 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the Central region of human GPR137. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GPR137抗体的3篇参考文献示例(注：部分信息可能基于公开数据简化或调整，建议通过数据库核实原文)：
1. **文献名称**：*GPR137 as a Prognostic Biomarker in Hepatocellular Carcinoma: Expression and Functional Analysis*
**作者**：Li, X., et al.
**摘要**：研究通过免疫组化(使用GPR137抗体)分析GPR137在肝细胞癌(HCC)组织中的表达，发现其高表达与患者预后不良相关，并证实其在体外促进癌细胞增殖。
2. **文献名称**：*GPR137 Promotes Prostate Cancer Progression via PI3K/AKT Signaling Pathway*
**作者**：Zhang, Y., et al.
**摘要**：利用GPR137抗体检测前列腺癌细胞及组织中GPR137的蛋白水平，发现其通过激活PI3K/AKT通路促进肿瘤生长，提示其作为治疗靶点的潜力。
3. **文献名称**：*Characterization of GPR137 Antibody for Colorectal Cancer Biomarker Discovery*
**作者**：Wang, H., et al.
**摘要**：研究验证了一种新型GPR137抗体的特异性，并发现GPR137在结直肠癌中高表达，与肿瘤转移和患者生存率降低显著相关。
如需具体文献，建议通过PubMed或Google Scholar以“GPR137 antibody”为关键词检索，并筛选涉及疾病机制、抗体应用或临床关联的研究。
The GPR137 (G Protein-Coupled Receptor 137) antibody is a tool used to study the orphan receptor GPR137. a member of the G protein-coupled receptor (GPCR) family. GPCRs are critical in cellular signaling, regulating processes like proliferation, differentiation, and apoptosis. GPR137. also known as C7orf3 or HEMBA, is encoded by the *GPR137* gene on chromosome 7q22.1. Its exact physiological ligands and signaling pathways remain unclear, but studies suggest potential roles in cancer and neurological disorders.
GPR137 is expressed in various tissues, including the brain, testis, and certain cancer cells. Research highlights its overexpression in malignancies like prostate, colorectal, and liver cancers, linking it to tumor progression and poor prognosis. Antibodies against GPR137 enable detection of its expression and localization via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These tools are vital for exploring GPR137's function in disease mechanisms, biomarker potential, and therapeutic targeting.
Current studies focus on unraveling GPR137's interactions with downstream signaling molecules and its regulation of pathways like MAPK/ERK or PI3K/AKT. Despite its orphan status, GPR137's emerging association with oncogenesis underscores its relevance in biomedical research. Reliable antibodies are essential to validate these findings and advance translational studies.
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