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Rabbit Polyclonal GIF Antibody

  • 中文名: GIF抗体
  • 别    名: Gastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH
货号: IPDX31192
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 1/10-1/50 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH
Entrez GeneID2694
WB Predicted band size45.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis GIF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the Central region of human GIF.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GIF抗体的3篇示例参考文献(内容为模拟概括,非真实文献):

1. **文献名称**:《Autoantibodies to Gastric Intrinsic Factor in Pernicious Anemia》

**作者**:Smith J, et al.

**摘要**:该研究分析了恶性贫血患者血清中的胃内在因子(GIF)自身抗体,证实其分为I型(阻断抗体)和II型(结合抗体),并探讨了其在疾病诊断中的敏感性及特异性。

2. **文献名称**:《Clinical Utility of Intrinsic Factor Antibody Testing》

**作者**:Lee R, Brown K.

**摘要**:文章评估了GIF抗体检测在自身免疫性胃炎和恶性贫血鉴别诊断中的应用,提出抗体检测联合维生素B12水平测定可提高早期诊断准确率。

3. **文献名称**:《Novel ELISA for Detection of Intrinsic Factor Autoantibodies》

**作者**:Zhang Y, et al.

**摘要**:研究开发了一种新型ELISA检测法,用于高效识别GIF抗体,对比传统方法显示更高灵敏度,为临床提供无创诊断工具。

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*注:以上为模拟文献,实际引用请通过PubMed或学术数据库查询真实研究。*

背景信息

GIF antibodies, targeting gastric intrinsic factor (GIF), are autoantibodies associated with autoimmune gastritis and pernicious anemia. Intrinsic factor, a glycoprotein secreted by gastric parietal cells, is essential for vitamin B12 absorption in the ileum. In autoimmune gastritis, the immune system mistakenly attacks parietal cells, impairing intrinsic factor production and leading to B12 deficiency. Two types of GIF antibodies are recognized: Type I (blocking antibodies) hinder B12 binding to intrinsic factor, while Type II (binding antibodies) prevent the B12-intrinsic factor complex from attaching to ileal receptors. These antibodies are detected in 50-70% of pernicious anemia cases, often coexisting with anti-parietal cell antibodies. Their presence supports diagnosis of autoimmune-related B12 deficiency and distinguishes it from other causes. Research highlights their role in disease progression, as chronic inflammation may lead to gastric atrophy and increased cancer risk. Testing for GIF antibodies aids in early intervention, particularly in patients with unexplained anemia or neurological symptoms linked to B12 deficiency. Studies also explore their potential as biomarkers for monitoring autoimmune gastritis severity and treatment response.

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