| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP, CRHBP, CRFBP |
| Entrez GeneID | 1393 |
| WB Predicted band size | 36.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRHBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human CRHBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CRHBP(N-term)抗体的3篇参考文献(文献信息为模拟示例，仅供参考)：
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1. **文献名称**: *Characterization of a Novel CRHBP N-Terminal Antibody for Neuroendocrine Studies*
**作者**: Smith A, et al.
**摘要**: 该研究开发并验证了一种针对CRHBP N端表位的高特异性多克隆抗体。通过Western blot和免疫组化实验证实其在啮齿类动物脑组织中能特异性识别CRHBP，并用于探究其在应激反应中的表达调控。
2. **文献名称**: *CRHBP Expression in Human Placenta: Insights from N-Terminal Antibody-Based Immunoassays*
**作者**: Lee J, et al.
**摘要**: 利用CRHBP(N-term)抗体进行胎盘组织免疫染色，揭示了CRHBP在妊娠早期与母胎界面的定位，提示其可能参与调节局部CRH信号通路以维持妊娠稳态。
3. **文献名称**: *Development of Monoclonal Antibodies Targeting CRHBP and Their Application in Metabolic Disease Models*
**作者**: Brown K, et al.
**摘要**: 研究团队制备了针对CRHBP N端的单克隆抗体，并通过ELISA和流式细胞术验证其结合能力。进一步实验显示，阻断CRHBP功能可能影响糖代谢，为肥胖相关疾病研究提供工具。
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注：以上文献为示例，实际引用需通过PubMed、Web of Science等平台检索具体文章。如需进一步协助定位真实文献，请提供更多研究背景或关键词。
The corticotropin-releasing hormone binding protein (CRHBP) is a key regulatory protein that modulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis by binding to corticotropin-releasing hormone (CRH) and related peptides. CRHBP acts as a buffer, controlling the bioavailability of CRH, which is central to stress response, immune regulation, and emotional behavior. The N-terminal region of CRHBP is critical for its interaction with CRH, influencing ligand-binding affinity and specificity.
Antibodies targeting the N-terminal domain of CRHBP (CRHBP N-term antibodies) are essential tools for studying the protein's expression, localization, and functional interactions. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry, and ELISA to detect CRHBP in tissues, serum, or cell lysates. They enable researchers to investigate CRHBP's role in stress-related disorders, metabolic syndromes, and psychiatric conditions like anxiety and depression.
CRHBP N-term antibodies are also valuable for exploring CRHBP's regulatory mechanisms, including its cleavage or post-translational modifications, which may alter CRH signaling pathways. Validated antibodies with high specificity ensure accurate detection, minimizing cross-reactivity with other CRH family proteins. Their applications extend to preclinical studies, aiding in the development of therapeutic strategies targeting CRH dysregulation. Proper validation using knockout controls or peptide-blocking assays is crucial to confirm antibody reliability in experimental models.
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