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Rabbit Polyclonal PAN3(C-term) Antibody

  • 中文名： PAN3 (C-term)抗体
  • 别    名： PAB-dependent poly(A)-specific ribonuclease subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}, PAB1P-dependent poly(A)-nuclease {ECO:0000255|HAMAP-Rule:MF_03181}, PAN deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181}, hPan3, PAN3 {ECO:0000255
货号: IPDX30612
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPAB-dependent poly(A)-specific ribonuclease subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}, PAB1P-dependent poly(A)-nuclease {ECO:0000255|HAMAP-Rule:MF_03181}, PAN deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181}, hPan3, PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
Entrez GeneID255967
WB Predicted band size95.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PAN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-799 amino acids from the C-terminal region of human PAN3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PAN3 (C-term)抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：

1. **文献名称**: "PAN3 C-terminal domain mediates interaction with deadenylase complexes in mRNA decay"

**作者**: Smith J, et al.

**摘要**: 本研究利用PAN3 C-term特异性抗体，通过免疫共沉淀实验证实PAN3的C端结构域与CCR4-NOT复合体相互作用，调控mRNA脱腺苷化和降解过程。

2. **文献名称**: "Localization and function of PAN3 in neuronal dendritic RNA processing"

**作者**: Lee H, et al.

**摘要**: 通过C-term抗体免疫荧光技术，发现PAN3富集于神经元树突中，并参与突触相关mRNA的稳定性调控，提示其在神经发育中的潜在作用。

3. **文献名称**: "A conserved role of PAN3 C-terminus in translational repression via poly(A) tail shortening"

**作者**: Garcia-Rodriguez N, et al.

**摘要**: 研究使用PAN3 C-term抗体进行Western blot分析，揭示PAN3通过C端结合PABP，介导poly(A)尾缩短及翻译抑制的分子机制。

注：以上文献为示例，实际文献需通过PubMed或学术数据库检索获取。建议使用关键词“PAN3 antibody C-terminal”结合实验类型(如Western blot、IP)进行精准搜索。

背景信息

The PAN3 (C-term) antibody is designed to target the C-terminal region of the Poly(A)-specific ribonuclease subunit PAN3. a critical component of the PAN2-PAN3 complex involved in mRNA deadenylation. This complex plays a key role in post-transcriptional gene regulation by shortening the poly(A) tails of eukaryotic mRNAs, a process essential for controlling mRNA stability, translation efficiency, and degradation. PAN3 contains distinct domains, including a pseudokinase domain and a C-terminal region that mediates interactions with PAN2 and other regulatory proteins. Antibodies against the C-terminal region (PAN3-C) are particularly useful for studying the structural and functional roles of PAN3 in deadenylation, as this region is critical for complex assembly and recruitment to target mRNAs. Researchers employ PAN3 (C-term) antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate PAN3 expression, localization, and interactions in various cellular contexts. These studies are vital for understanding PAN3's involvement in developmental processes, cellular homeostasis, and diseases linked to dysregulated mRNA turnover, such as cancer or neurological disorders. The antibody's specificity for the C-terminal epitope ensures minimal cross-reactivity, making it a reliable tool for dissecting PAN3-dependent mechanisms in molecular and cell biology research.

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